COL18A1, collagen type XVIII alpha 1 chain, 80781

N. diseases: 323; N. variants: 41
Disease: Solid Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Our findings suggested that endostatin decreased the number of microvessels via the HIF-1/VEGF signaling pathway, and that pEgr-1-endostatin combined with IR may improve hypoxic conditions and may be a novel approach for treating solid tumors. 28454220 2017
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Based on our findings, Ad-endostatin combined with low-dose irradiation may be a rational alternative treatment for lung cancer and other solid tumors. 24927253 2014
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Recombinant human endostatin (rEndostatin or endostar) has been shown to inhibit endothelial cells proliferation, migration, and angiogenesis and exhibits a broad spectrum of activities against solid tumors. 24908076 2014
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE The STAT3 decoy oligonucleotidewas found to be an effective antiangiogenic agent, which is likely to contribute to the overall antitumor effects of this agent in solid tumors.Taken together with the previously demonstrated antitumor activity of this agent, STAT3 decoy oligonucleotide represents a promising single agent approach to targeting both the tumor and vascular compartments in various malignancies. 24404126 2014
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE These observations provide further evidence of the antitumor effect of endostatin gene therapy, and may be of importance for further exploration of potential application of this combined approach in the treatment of human lung cancer as well as other solid tumors. 18939902 2009
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 GeneticVariation phenotype BEFREE A phase I clinical trial of an adenovirus-mediated endostatin gene (E10A) in patients with solid tumors. 17426445 2007
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 GeneticVariation phenotype BEFREE E10A, a recombinant adenovirus type 5 vector carrying the human endostatin gene, may be a promising gene therapy drug in the treatment of solid tumors by antiangiogenesis, but a preclinical safety evaluation of E10A has not yet been performed. 17346097 2007
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Lower level or impaired function of endostatin is associated with a higher risk of developing malignant solid tumors and with a worse prognosis of the disease. 15735323 2005
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 AlteredExpression phenotype BEFREE Combination angiostatin and endostatin gene transfer induces synergistic antiangiogenic activity in vitro and antitumor efficacy in leukemia and solid tumors in mice. 11237675 2001
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Purified recombinant mouse endostatin protein has been reported to regress established murine solid tumors by inhibiting the proliferation of endothelial cells. 11242527 2001
CUI: C0280100
Disease: Solid Neoplasm
Solid Neoplasm 		0.100 Biomarker phenotype BEFREE Indeed, the efficacy of endogenous angiogenesis inhibitors, including angiostatin, endostatin and TIMPs, has been demonstrated in many types of solid tumors in animal models. 10669955 2000