CALM3, calmodulin 3, 808

N. diseases: 215; N. variants: 3
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE The CD146 (also known as MCAM, MUC-18, Mel-CAM) was initially reported in 1987, as a protein crucial for the invasiveness of malignant melanoma. 31826047 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE A 4-mm punch biopsy showed a poorly differentiated tumor with cells that were positive for CAM 5.2 and cytokeratin 20 in a dotlike paranuclear pattern and negative for cytokeratin 5/6, human melanoma black 45, and leukocyte common antigen. 29763480 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE To evaluate the potential role of FGF-2, beta3 integrin and Mel-CAM in melanoma development we overexpressed FGF-2, beta3 integrin and Mel-CAM in normal human melanocytes using replication-deficient adenoviruses as a gene delivery vehicle. 12823444 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE Mel-CAM-specific genetic suppressor elements inhibit melanoma growth and invasion through loss of gap junctional communication. 11498790 2001
CUI: C0025202
Disease: melanoma
melanoma 		0.060 Biomarker disease BEFREE Mel-CAM was originally described as a marker associated with invasion and metastasis in melanoma. 9284823 1997
CUI: C0025202
Disease: melanoma
melanoma 		0.060 AlteredExpression disease BEFREE TPA markedly inhibited expression of all three CaM genes in melanocytes; however, in melanomas the net effect of TPA was to increase their expression. 1469290 1992