|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
The two prevalent phenotypes are long QT syndrome (LQTS; CALM-LQTS, n = 36, 49%) and catecholaminergic polymorphic ventricular tachycardia (CPVT; CALM-CPVT, n = 21, 28%).
|
31170290 |
2019 |
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.340 |
Biomarker
|
disease |
BEFREE |
Mutations in human genes CALM1, CALM2, and CALM3 have been associated with life-threatening heart disorders, such as long QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia.
|
30937913 |
2019 |
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
To that end, we have designed a CaM protein (GSH-M37Q; dubbed as therapeutic CaM or T-CaM) that exhibited a slowed N-terminal Ca dissociation rate and prolonged RyR2 refractoriness in permeabilized myocytes derived from CPVT mice carrying the CASQ2 mutation R33Q.
|
29720499 |
2018 |
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
We identified a novel CaM mutation-A103V-in CALM3 in 1 of 12 patients (8%), a female who experienced episodes of exertion-induced syncope since age 10, had normal QT interval, and displayed ventricular ectopy during stress testing consistent with CPVT.
|
27516456 |
2016 |
|
VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)
|
0.340 |
GeneticVariation
|
disease |
ORPHANET |
|
|
|
|
Syncope
|
0.110 |
GeneticVariation
|
phenotype |
BEFREE |
We identified a novel CaM mutation-A103V-in CALM3 in 1 of 12 patients (8%), a female who experienced episodes of exertion-induced syncope since age 10, had normal QT interval, and displayed ventricular ectopy during stress testing consistent with CPVT.
|
27516456 |
2016 |
|
Syncope
|
0.110 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is therefore relevant and timely to determine if CAM biomarkers can be identified and developed to guide cancer diagnosis and treatment.
|
30834992 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Integration of CAM therapies in standard cancer care should be encouraged to complement cancer treatment.
|
30935516 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interest in CAM prior to cancer diagnosis, CAM interest since diagnosis, CAM use and disclosure of CAM use to doctors.
|
31331555 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
RASS dispersion correlates highly with CAM-ICU positivity, and monitoring trends in RASS scores can identify delirium caused by new brain injuries.
|
30506177 |
2019 |
|
Delirium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Continued education about the CAM-ICU tool is still needed; additionally addressing barriers within the structure of the unit to provide nurses more resources to properly assess and prevent delirium.
|
30899957 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that the Chinese version of CAM-S has good reliability and validity in evaluating postoperative delirium in geriatric Chinese patients and may be a useful tool to assess the severity of delirium.
|
31127777 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
Primary outcomes were delirium duration measured by the CAM-ICU and severity measured by the Delirium Rating Scale Revised-98 (DRS-R-98) and the CAM-ICU-7; secondary outcomes included adverse events and mortality.
|
30664239 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, delirium will be assessed preoperatively and postoperatively in the hospital using the Confusion Assessment Method (3D-CAM).
|
30804030 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
Severity of cognitive impairment (Montreal Cognitive Assessment [MoCA]), delirium presence (Confusion Assessment Method [CAM]), and delirium severity (CAM-Severity [CAM-S]) were measured during hospitalization and at 1-month follow-up.
|
31605539 |
2019 |
|
Delirium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients were screened for delirium using CAM-ICU method.
|
31695347 |
2019 |
|
Delirium
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients were assessed for delirium within 1 hour of EEG with the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) and 3D-CAM severity score.
|
31467255 |
2019 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stratified analysis found a higher incidence of delirium in baseline CAM-ICU-positive patients who experienced emergency surgery within 24 hours of admission compared with baseline CAM-ICU-negative patients after melatonin administration.
|
30920404 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
CCAAT/enhancer-binding protein alpha (CEBPA) gene haploinsufficiency does not alter hematopoiesis or induce leukemia in Lck-CALM/AF10 transgenic mice.
|
31141090 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways.
|
30670779 |
2019 |
|
leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we demonstrate that the Polycomb Repressive Complex 1 gene BMI1 is consistently overexpressed in adult and pediatric CALM-AF10-positive leukemias.
|
31022428 |
2019 |
|
Multiple Myeloma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Intriguingly, miR-182 up-regulation could promote CAM-DR in H929 and MM.1S cells.
|
31540771 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cancer experts reported higher CAM-MYCS scores (fewer myths endorsed) than students (p<0.001).
|
30552257 |
2018 |
|
Delirium
|
0.100 |
Biomarker
|
disease |
BEFREE |
The principal exposures were FSD and SSD compared to no delirium (as measured by the CAM), along with individual delirium symptoms on the CAM.
|
29370764 |
2018 |