|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.
|
30285260 |
2019 |
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
|
31268507 |
2019 |
|
Bipolar Disorder
|
0.110 |
Biomarker
|
disease |
BEFREE |
Genetic variants of the fragile X mental retardation syndrome-related protein 1 (<i>FXR1)</i> have been associated to mood regulation, schizophrenia, and bipolar disorders.
|
29706865 |
2018 |
|
Schizophrenia
|
0.110 |
Biomarker
|
disease |
BEFREE |
Association between the Gsk3β-Fxr1 pathway and glutamatergic signaling also suggests how it may contribute to emotional regulation in response to mood stabilizers, or in illnesses like mood disorders and schizophrenia.
|
29706865 |
2018 |
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
|
29483656 |
2018 |
|
Bipolar Disorder
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.
|
26433762 |
2016 |
|
Eating Disorders
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.
|
26433762 |
2016 |
|
Eating Disorders
|
0.110 |
GeneticVariation
|
group |
BEFREE |
The most significant genome-wide finding was observed bipolar with comorbid eating disorder vs. controls within SOX2-OT (p=8.9×10(-8) for rs4854912) with a secondary peak in the adjacent FXR1 gene (p=1.2×10(-6) for rs1805576) on chromosome 3q26.33.
|
26433762 |
2016 |
|
Schizophrenia
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
|
31374203 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Other eating disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
A genome-wide association study of bipolar disorder with comorbid eating disorder replicates the SOX2-OT region.
|
26433762 |
2016 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
RNA-sequencing of FXR1 was performed from WT and other pediatric malignancies to examine its broader target potential.
|
30894247 |
2019 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our study anticipates that inhibition of FXR1 is a potential therapeutic approach to targeting human cancers harboring <i>TP53</i> homozygous deletion.
|
28767039 |
2017 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Moreover, IHC results showed that cancer tissues possessed higher FXR1 expression (P = 0.027).
|
26404134 |
2016 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Silencing of FXR1 in cancer cells triggers the activation of Cyclin-Dependent Kinase Inhibitors, p53, increases DNA damage, and ultimately, cellular senescence.
|
27606879 |
2016 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Because FXR1 is overexpressed and associated with poor clinical outcomes in multiple cancers, these results have implications for other solid malignancies.
|
25733852 |
2015 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Collectively, PKP1/3-associated RBPs FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis and highlight the potential importance of posttranscriptional regulation of gene expression and nonsense-mediated decay in cancer.
|
23881279 |
2013 |
|
Fragile X Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
The functions of FXR1P and FXR2P and their possible roles in producing or modulating the phenotype observed in FXS are yet to be identified.
|
30654445 |
2019 |
|
Fragile X Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
We report a functional association between lamin A and fragile X-related protein 1 (FXR1P), a protein of the fragile X-related family involved in fragile X syndrome.
|
24108105 |
2014 |
|
Fragile X Syndrome
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The Fragile X-Related 1 gene (FXR1) is a paralog of the Fragile X Mental Retardation 1 gene (FMR1), whose absence causes the Fragile X syndrome, the most common form of inherited intellectual disability.
|
23555284 |
2013 |
|
Fragile X Syndrome
|
0.050 |
Biomarker
|
disease |
BEFREE |
The Fragile X Mental retardation-Related 1 (FXR1) gene belongs to the fragile X related family, that also includes the Fragile X Mental Retardation (FMR1) gene involved in fragile X syndrome, the most common form of inherited mental retardation.
|
18628314 |
2008 |