Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate.
|
31009812 |
2019 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Fine mapping in TERT-CLPTM1L region identified three independent lung cancer susceptibility signals: A large-scale multi-ethnic population study.
|
29809284 |
2018 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous genome-wide association study observed that rs401681 within CLPTM1L (CLPTM1 like) was significantly associated with lung cancer.
|
29939218 |
2018 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Individuals, including the smoking population, who carry both the TERT rs2736098 and CLPTM1L rs401681 T alleles are more likely to develop lung cancer.
|
28789383 |
2017 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Several genome-wide association studies (GWAS) have identified TERT-CLPTM1L as plausible causative locus for lung cancer development.
|
27982019 |
2017 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Malignant neoplasm of lung
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry was used to examine CLPTM1L expression levels on a tissue microarray containing 73 sets of human lung cancer specimens with adjacent normal tissue.
|
27062701 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that certain CLPTM1L polymorphisms are protective factors against lung cancer in a southern Chinese Han population and may be potential diagnostic and molecular markers for lung cancer patients.
|
26852039 |
2016 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We observed statistically significant associations with melanoma for two lung cancer SNPs in the TERT-CLPTM1L locus (Bonferroni-corrected p<2.8x10-4), replicating known pleiotropic effects at this locus.
|
25789475 |
2015 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)).
|
26138067 |
2015 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The differences in risk level between Israeli Jews and non-Jews could not be explained by lung cancer genetic risk variants which were identified in GWAS (genes in the CHRNA5, TERT and CLPTM1L regions).
|
25924736 |
2015 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study examined associations between five single nucleotide polymorphisms (SNPs) of TERT-CLPTM1L (rs402710, rs401681, rs465498, rs4975616, and rs2736100) and lung cancer in a Chinese Han population in the Hubei Province.
|
25966219 |
2015 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, our results establish a protumorigenic role for CLPTM1L that is critical for Ras-driven lung cancers, with potential implications for therapy and chemosensitization.
|
24366883 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in TERT-CLPTM1L genes and risk of lung cancer in a Chinese population.
|
24761905 |
2014 |
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
CTD_human |
Taken together, our results establish a protumorigenic role for CLPTM1L that is critical for Ras-driven lung cancers, with potential implications for therapy and chemosensitization.
|
24366883 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 23 single nucleotide polymorphisms (SNPs) in the five nicotinic receptor related genes (CHRNB3, CHRNA6, and CHRNA5/A3/B4) previously reported to be associated with lung cancer risk and smoking behavior and 14 SNPs in the four 'control' genes (TERT, CLPTM1L, CYP1A1, and TP53), which were not reported in the smoking GWA studies.
|
25233467 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the association between polymorphisms in TERT and CLPTM1L genes with the risk of lung cancer, as well as the interaction of the polymorphisms and the environmental risk factors in Chinese non-smoking females.
|
25037574 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between CLPTM1L polymorphisms (rs402710 and rs401681) and lung cancer susceptibility: evidence from 27 case-control studies.
|
24907075 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results verified that genetic variants of CLPTM1L contribute to lung cancer susceptibility in the northwest Chinese Han population.
|
25526467 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
However, the joint effect of TERT and CLPTM1L variants increased the risk of lung cancer, especially squamous cell carcinoma, with an adjusted OR of 3.274.
|
24861918 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results of the present study suggest a potential association between CLPTM1L variants and lung cancer risk in the Chinese Han populations.
|
25155038 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis provides supportive evidence that CRR9p polymorphism may influence a risk of LC and NSCLC in a protective model.
|
24957041 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variant in CLPTM1L confers reduced risk of lung cancer: a replication study in Chinese and a meta-analysis.
|
25422207 |
2014 |
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |