|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in TERT and CLPTM1L may affect the susceptibility of lung cancer, especially adenocarcinoma in Chinese women nonsmokers.
|
23738012 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The GA genotype of CLPTM1L was inversely associated with lung cancer (OR=0.72, 95% CI: 0.54-0.97).
|
23433592 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies and consecutive validation supported that the 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in multiple populations.
|
23368278 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common genetic polymorphisms on chromosome 5p15.33, including rs401681 in cleft lip and palate transmembrane 1-like gene (CLPTM1L), have been implicated in susceptibility to lung cancer through genome-wide association studies (GWAS); however, subsequent replication studies yielded controversial results.
|
23653681 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the logistic regression analysis, TERT-rs2853669, rs2736108, and CLPTM1L-rs31490 were significant associated with increased risk of lung cancer (OR = 1.46, 95% CI = 1.22-1.75; OR = 1.22, 95% CI = 1.00-1.49 and OR = 1.74, 95% CI = 1.35-2.23 under additive model, respectively).
|
23908149 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that genetic variants in the TERT-CLPTM1L gene may predispose individuals to be susceptible to LC, particularly NSCLC, in the Chinese population.
|
23359026 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Longer telomere length in peripheral white blood cells is associated with risk of lung cancer and the rs2736100 (CLPTM1L-TERT) polymorphism in a prospective cohort study among women in China.
|
23555636 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A common sequence variant, rs401681, located in an intronic region of CLPTM1L, has been reported to be associated with lung cancer risk based on genome-wide association study.
|
24386361 |
2013 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
Functional characterization of CLPTM1L as a lung cancer risk candidate gene in the 5p15.33 locus.
|
22675468 |
2012 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
CLPTM1L transferred lung cancer cell line 95-D showed no growth inhibition or cell apoptosis, but it did show inhibited sensitivity to cis-diamminedichloroplatinum(II) (cisplatin, CDDP).
|
23300716 |
2012 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively).
|
21725308 |
2011 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The TERT-CLPTM1L locus for lung cancer predisposes to bronchial obstruction and emphysema.
|
21622582 |
2011 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, our results show that genetic variation in the CLPTM1L-TERT locus of chromosome 5p15.33 is directly associated with the risk of lung cancer, most notably adenocarcinoma.
|
20700438 |
2010 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This analysis provides evidence that TERT-CLPTM1L variants may influence the risk of lung cancer outside the context of tobacco smoking.
|
19955392 |
2010 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
CTD_human |
Sequence variants at the TERT-CLPTM1L locus associate with many cancer types.
|
19151717 |
2009 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data demonstrate a potential association between the TERT-CLPTM1L variant and levels of bulky DNA adducts measured by (32)P-postlabeling and hence a basis for susceptibility to the development of lung cancer.
|
19465454 |
2009 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 5p15.33, containing TERT and CLPTM1L genes, was recently identified as one of the susceptible regions for lung cancer in Caucasian populations.
|
19369581 |
2009 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
BEFREE |
The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology.
|
18978790 |
2008 |
|
Malignant neoplasm of lung
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
Malignant neoplasm of lung
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
Non-Small Cell Lung Carcinoma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations.
|
31326317 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to investigate the associations of genetic variations in TERT-CLPTM1L and the expression level of TERT with the survival of early stage non-small cell lung cancer (NSCLC) patients.
|
27982019 |
2017 |