TCL1A, T cell leukemia/lymphoma 1A, 8115

N. diseases: 106; N. variants: 2
Disease: Richter's syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0349631
Disease: Richter's syndrome
Richter's syndrome 		0.020 Biomarker disease BEFREE Upon B cell-specific deletion of NFAT2, TCL1 transgenic mice develop a disease resembling human Richter's syndrome. 30556925 2019
CUI: C0349631
Disease: Richter's syndrome
Richter's syndrome 		0.020 Biomarker disease BEFREE <i>In vivo</i>, ARQ 531 was found to increase survival over ibrutinib in a murine Eμ-TCL1 engraftment model of CLL and a murine Eμ-MYC/TCL1 engraftment model resembling Richter transformation. 30093506 2018