|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This provides a neurodevelopmental mechanism for how dysregulation of ST8SIA2 may lead to disturbed inhibitory balance as observed in schizophrenia and autism.
|
31608978 |
2020 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Among the six ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferases (ST8SIA) existing in adult brains, ST8SIA2 is a schizophrenia-associated gene.
|
31455764 |
2019 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that the expression level of the ST8SIA2 gene is a genetic determinant of schizophrenia risk, and we found that a geographically differentiated non-risk SNP type (CGC-type) has significantly reduced promoter activity.
|
30044798 |
2018 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study examined the extent to which specific haplotypes in ST8SIA2 influence white matter microstructure using diffusion-weighted imaging of individuals with schizophrenia (n = 281) and healthy controls (n = 172), recruited across five Australian sites.
|
29353880 |
2018 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, to clarify this point, we first prepared polySia-NCAMs from HEK293 cells stably expressing ST8SIA4 and ST8SIA2, or ST8SIA2 (SNP-7), a mutant ST8SIA2 derived from a schizophrenia patient.
|
28810663 |
2017 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
ST8SIA2 is a schizophrenia candidate gene, and St8sia2<sup>-/-</sup> mice exhibit schizophrenia-like behavior.
|
27534376 |
2017 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Impairments of the polySia-expression and several single nucleotide polymorphisms (SNPs) of the polysialyltransferase (polyST) ST8SIA2 gene are reported to be associated with schizophrenia and bipolar disorder.
|
28538701 |
2017 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the genetic association between ST8SIA2 and both schizophrenia and BD in the Korean population.
|
26418860 |
2015 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
These results reveal that reduced polysialylation in St8sia2 (-/-) mice leads to pathological brain development and schizophrenia-like behavior.
|
24057454 |
2015 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Sex-specific association of the ST8SIAII gene with schizophrenia in a Spanish population.
|
24070986 |
2013 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Sex-specific association of the ST8SIAII gene with schizophrenia in a Spanish population.
|
24070986 |
2013 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we recapitulate the biosynthesis of polysialic acid by the two polysialyltransferases ST8SIA2 and ST8SIA4 and highlight the increasing evidence that variation in the human ST8SIA2 gene is linked to schizophrenia and possibly other neuropsychiatric disorders.
|
23354723 |
2013 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
By a fine mapping association study in an Australian case-control cohort (n = 385), we find that the sialyltransferase 8B (ST8SIA2) gene, coding for an enzyme that glycosylates proteins involved in neuronal plasticity which has previously shown association to both schizophrenia and autism, is associated with increased risk to bipolar spectrum disorder.
|
22693595 |
2012 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
By a fine mapping association study in an Australian case-control cohort (n = 385), we find that the sialyltransferase 8B (ST8SIA2) gene, coding for an enzyme that glycosylates proteins involved in neuronal plasticity which has previously shown association to both schizophrenia and autism, is associated with increased risk to bipolar spectrum disorder.
|
22693595 |
2012 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this region, the putative susceptibility gene ST8SIA2 (also known as SIAT8B) was recently associated with SZ in a Japanese sample.
|
16969366 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Our findings indicate that SIAT8B may be a candidate susceptibility gene for schizophrenia in the Chinese Han population and may also provide further support for the potential importance of polysaccharide-synthesizing genes in the etiology of schizophrenia.
|
17126533 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In this region, the putative susceptibility gene ST8SIA2 (also known as SIAT8B) was recently associated with SZ in a Japanese sample.
|
16969366 |
2007 |
|
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that SIAT8B may be a candidate susceptibility gene for schizophrenia in the Chinese Han population and may also provide further support for the potential importance of polysaccharide-synthesizing genes in the etiology of schizophrenia.
|
17126533 |
2007 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests that functional promoter SNPs of SIAT8B could confer a risk for schizophrenia in the Japanese population.
|
16229822 |
2006 |
|
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The present study suggests that functional promoter SNPs of SIAT8B could confer a risk for schizophrenia in the Japanese population.
|
16229822 |
2006 |