SLC7A5, solute carrier family 7 member 5, 8140

N. diseases: 173; N. variants: 3
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE 2-[<sup>18</sup>F]FELP, a novel LAT1-specific PET tracer, for the discrimination between glioblastoma, radiation necrosis and inflammation. 31841816 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE New fluoroethyl phenylalanine analogues as potential LAT1-targeting PET tracers for glioblastoma. 30814660 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression disease BEFREE The present study showed that even one course of BEV administration induced reductions in microvessels, vascular pericytes, and LAT1 expression in glioblastomas. 31446307 2019
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE Xenopus laevis oocytes expressing human LAT1 together with the glycoprotein 4F2hc (necessary to pull LAT-1 to the plasma membrane) exhibited a similar accumulation of FET as observed in glioblastoma cells. 25385314 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 Biomarker disease BEFREE We have focused our attention on the PDZ domain from hCASK (Human calcium/calmodulin-dependent serine protein kinase) that binds extracellular CD98 in epithelial cells, being this antigen recognized as a marker for several human tumors and particularly considered a negative prognostic marker for human glioblastoma. 25581839 2015
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression disease BEFREE LAT1 mRNA and protein expression varies in GBM, and the extent of (3)H-L-DOPA uptake was positively correlated with endogenous LAT1 expression. 23086431 2013