SLC7A5, solute carrier family 7 member 5, 8140

N. diseases: 173; N. variants: 3
Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.050 GeneticVariation disease BEFREE rs4240803 impacted the expression of SLC7A5, thus contributing to the clinical response of MM patients to melphalan therapy. 30591441 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.050 Biomarker disease BEFREE Here, we evaluated the use of 3,4-dihydroxy-6-<sup>18</sup>F-fluoro-l-phenylalanine (<sup>18</sup>F-FDOPA), a clinically available PET radiotracer with specificity to the L-type amino acid transporter 1 (LAT1), which also mediates melphalan uptake, for imaging melphalan therapy response in a preclinical immunocompetent model of MM. 29700126 2018
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.050 GeneticVariation disease BEFREE A single nucleotide polymorphism in SLC7A5 is associated with gastrointestinal toxicity after high-dose melphalan and autologous stem cell transplantation for multiple myeloma. 24704384 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.050 Biomarker disease BEFREE Thus, LAT1 may be a promising pathological marker for identifying high-risk MM. 25220100 2014
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.050 AlteredExpression disease BEFREE All myeloma cells from 4 cases expressed CD98 at a high level and incorporated melphalan. 10940652 2000