DOCK8, dedicator of cytokinesis 8, 81704

N. diseases: 112; N. variants: 24
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 Biomarker disease BEFREE Serum samples were collected from DOCK8-deficient (<i>n</i> = 10) and AD (<i>n</i> = 9) patients. 31718082 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 Biomarker disease BEFREE Quantitative profiling of cytokines and chemokines in DOCK8-deficient and atopic dermatitis patients. 30252138 2019
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 GeneticVariation disease BEFREE Mutations of DOCK8 in humans cause a combined immunodeficiency characterized by atopic dermatitis with high serum IgE levels. 28067314 2017
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 AlteredExpression disease BEFREE This study provides new insights on the mechanisms of stress-induced AD aggravation by showing that CRH downregulated DOCK8 expression in Tregs that not only clinically correlates with anxiety levels of AD patients but also regulates suppressive function of Tregs on CD4(+) T cells. 26799599 2016
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 Biomarker disease BEFREE DOCK8 disruption is associated with a phenotype of severe cellular immunodeficiency characterized by susceptibility to viral infections, atopic eczema, defective T-cell activation and T(h)17 cell differentiation, and impaired eosinophil homeostasis and dysregulation of IgE. 20004785 2009
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.150 Biomarker disease HPO