|
Forced expiratory volume function
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
|
30804560 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms.
|
25574825 |
2015 |
|
Psoriasis vulgaris
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.
|
26626624 |
2015 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Psoriasis
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity.
|
23143594 |
2012 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
In the particular case of benzo[a]pyrene induction of K-Ras codon 12 TGT mutation in the A/J mouse lung, measurement of tumor-associated oncomutation was shown to be an earlier and more sensitive endpoint than tumor response.
|
20740637 |
2010 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Sequence analysis of tumor DNA revealed that GGT (Gly) was replaced by GAT (Asp; 35%), GTT (Val; 32%), AGT (Ser; 13%), GCT (Ala; 10%), TGT (Cys; 8%), and CGT (Arg; 2%) for codon 12, and by GAC (Asp) as the only type of mutation for codon 13.
|
14760087 |
2004 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Eight cases had mutations concurrently in different areas of the same tumor and in all of these the mutation was homogeneous (6 cases to GAT, 1 case to TGT and 1 case to GTT).
|
8514605 |
1993 |
|
Multiple Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
For this reason and because of the recent finding that mammalian TGT may be utilized for the treatment of multiple sclerosis, this enzyme is of potential medical relevance, rendering detailed knowledge of its biochemistry and structural architecture highly desirable.
|
29862811 |
2018 |
|
Multiple Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The data suggest that exploitation of the eukaryotic TGT enzyme is a promising approach for the treatment of multiple sclerosis.
|
28204548 |
2017 |
|
Ischemic stroke
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed that TGC and TGT haplotypes were associated with decreased risk of IS (OR = 0.59, 95% CI: 0.40~0.87, P = 0.007 for TGC haplotype; OR = 0.21, 95% CI: 0.06~0.75, P = 0.009 for TGT haplotype).
|
31703587 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
The haplotype CAC may be a protective factor against breast cancer, and CGT, TAC, and TGT may be risk factors for breast cancer.
|
29748526 |
2018 |
|
Hypodysfibrinogenemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Hypodysfibrinogenemia with a Heterozygous Mutation of γCys326Ser by the Novel Transversion of TGT to TCT in a Patient with Pulmonary Thromboembolism and Right Ventricular Thrombus.
|
28419986 |
2018 |
|
Pulmonary Thromboembolisms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypodysfibrinogenemia with a Heterozygous Mutation of γCys326Ser by the Novel Transversion of TGT to TCT in a Patient with Pulmonary Thromboembolism and Right Ventricular Thrombus.
|
28419986 |
2018 |
|
Right ventricular thrombus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hypodysfibrinogenemia with a Heterozygous Mutation of γCys326Ser by the Novel Transversion of TGT to TCT in a Patient with Pulmonary Thromboembolism and Right Ventricular Thrombus.
|
28419986 |
2018 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The haplotype CAC may be a protective factor against breast cancer, and CGT, TAC, and TGT may be risk factors for breast cancer.
|
29748526 |
2018 |
|
Thrombocythemia, Essential
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A haplotype analysis found that the GGT and TGT haplotypes had significantly different distributions between ET and controls (p = 0.041 and 0.041, respectively).
|
27990849 |
2017 |
|
Shigella Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
A null mutation in the tgt gene encoding the tRNA-modifying enzyme tRNA-guanine transglycosylase (Tgt) was found to drastically decrease the pathogenicity of Shigella bacteria, suggesting the use of Tgt as putative target for selective antibiotics.
|
25951081 |
2015 |
|
Colorectal Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In NSCLC GLY12Cys mutations, resulting from a codon 12 GGT>TGT substitution, were observed in 44% compared to 10% for CRC.
|
24331409 |
2014 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In accordance, haplotypic analysis of the three polymorphisms also showed that the haplotype block CGC* and TGC* were significantly associated with HBsAg seroclearance (P<0.05) while haplotype block CAT*, CGT*, TAC* and TGT* were significantly associated with HBV-associated HCC (all P<0.05).
|
24867713 |
2014 |
|
Seizures
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Further, low protein-expressing CGT and TGT (c.-24C>T, c.1249G>A, c.3972C>T) haplotypes were always observed to be present in combination with the AG (c.-1549G>A, c.-1019A>G) haplotype that was over-represented in women with 'no seizures'.
|
22565165 |
2012 |
|
Parathyroid Adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The mutation S33C (TCT>TGT) was detected by direct-DNA sequencing of PCR fragments in 1 out of 180 sporadic parathyroid adenomas (0.68 %).
|
22576020 |
2012 |
|
Mycosis Fungoides
|
0.010 |
Biomarker
|
group |
BEFREE |
The 5 and 50 mg/kg dose groups had TGT MFs significantly higher than did controls.
|
19658153 |
2010 |
|
Myotonia Fluctuans (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
The 5 and 50 mg/kg dose groups had TGT MFs significantly higher than did controls.
|
19658153 |
2010 |