melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using the melanoma mouse model Tg(Grm1), MIA-deficient mice supported the impact of MIA on senescence by showing a significantly earlier tumor onset compared to controls.
|
31172672 |
2019 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MIA has a pivotal role in the progression and metastasis of melanoma; MIA2 and TANGO have been suggested to possess tumor-suppressive functions; and OTOR is uniquely expressed in cochlea of the inner ear.
|
29655307 |
2018 |
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Keratin genes, MIA family genes, fatty acid-related genes, and melanoma-associated genes were also differentially regulated, which suggests that they may play important roles in coat color formation.
|
28974924 |
2018 |
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
NMR-based Drug Development and Improvement Against Malignant Melanoma - Implications for the MIA Protein Family.
|
28595551 |
2017 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
S100 and MIA are highly sensitive tumor markers for monitoring of patients with melanoma with current metastases, but less sensitive for monitoring of tumor-free patients.
|
28870930 |
2017 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We identified melanoma inhibitory activity (MIA) as a direct target gene of SOX10, which is an essential protein for melanoma cell migration and invasion.
|
24608986 |
2014 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Uncovering new potential downstream effectors working via activation of YBX1 supports the important role of MIA in melanoma.
|
23672612 |
2013 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In ACC, BBC, and melanoma (MEL), SOX10 expression strongly co-segregated with the expression of ROPN1B, GPM6B, COL9A3, and MIA.
|
23799842 |
2013 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, PEDF downregulated S100β and melanoma inhibitory activity, which are widely used in the pathological diagnosis of melanoma.
|
21673604 |
2011 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma inhibitory activity (MIA) has been shown to play an essential role in the progression of malignant melanoma and to influence melanoma-associated molecules and pathways in the early tumor formation steps.
|
21642354 |
2011 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these findings suggest that cadherin-7 regulates the expression and activity of MIA and the migration of melanoma cells playing a role in tumor development of malignant melanoma.
|
19200257 |
2009 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Multimarker real-time reverse transcription-PCR for quantitative detection of melanoma-associated antigens: a novel possible staging method.
|
18181974 |
2008 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We compared MIA serum levels in two groups of patients with primary melanoma; those with positive as opposed to those with negative sentinel lymph nodes.
|
18477894 |
2008 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
We compared 3 tumor markers, TA90-immune complex (TA90IC), melanoma-inhibiting activity (MIA) protein, and S100B protein in Stage III melanoma patients undergoing adjuvant vaccine immunotherapy.
|
17661202 |
2007 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Influence of melanoma inhibitory activity on transforming growth factor-beta signaling in malignant melanoma.
|
16845326 |
2006 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Melanoma inhibitory activity (MIA) is an 11 kD protein secreted by malignant melanomas.
|
15386421 |
2005 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
These results suggest that expression of MIA promotes melanoma progression by inducing further melanoma-associated genes.
|
15208686 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genes MIA (melanoma inhibitory activity) and PLA2G2A (phospholipase A2, group IIA) show the highest specificity as cardiac myxoma markers, since they have more than 10-fold higher RNA level in cardiac myxomas than in any one of 15 normal tissues tested.
|
15350845 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The goal of this study was to determine the effect of ultraviolet radiation (UVR), activating ras mutation, or loss of p53 function on MIA expression and release from melanoma cells.
|
15201995 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma.
|
15118759 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Twenty-seven of 36 serum GPC3-positive patients were negative for both serum 5-S-cysteinyldopa and melanoma-inhibitory activity, well-known tumor markers for melanoma.
|
15475451 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Melanoma inhibitory activity, secreted by melanoma cells, is known to inhibit tumour cell attachment to the extracellular matrix enhancing their invasive potential.
|
15057037 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The melanoma inhibitory activity (MIA) protein is a clinically valuable marker in patients with malignant melanoma as enhanced values diagnose metastatic melanoma stages III and IV.
|
12592021 |
2003 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
In summary, our study proves HMG1 and p65 to be important factors in MIA regulation and melanoma progression.
|
12665595 |
2003 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data indicate that the enhancer/tyrosinase and enhancer/MIA promoter constructs but not the viral promoter constructs can provide a valuable tool for selective suicide gene expression in melanoma.
|
14714561 |
2003 |