GDF5, growth differentiation factor 5, 8200

N. diseases: 238; N. variants: 24
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.230 Biomarker disease BEFREE Growth/differentiation factor-5 (GDF-5), a member of the transforming growth factor-beta (TGF-β) superfamily, has been shown to protect rat dopaminergic neurons against insult both in embryonic neuronal culture and in Parkinson's disease models. 28458020 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.230 Biomarker disease RGD It found that endogenous GDF5, GDNF and their receptors are differentially expressed in two 6-hydroxydopamine lesion models of PD. 24373993 2014
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.230 Biomarker disease BEFREE The neurotrophin growth/differentiation factor 5 (GDF5) is studied as a potential therapeutic agent for Parkinson's disease as it is believed to play a role in the development and maintenance of the nigrostriatal system. 21858606 2012
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.230 Biomarker disease BEFREE This study provides the first proof-of-principle that sustained delivery of GDF5 in vivo may be useful in the treatment of PD. 22436046 2012