|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AIB1 predicts tumor response to definitive chemoradiotherapy and prognosis in cervical squamous cell carcinoma.
|
31602272 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AIB1 (high vs. low) was associated to BCM in multivariable analysis (adjusted for age, tumor size, nodal status, NHG, Ki67, luminal-like classification, and adjuvant systemic therapy) with 10-year FU (HR 6.8, 95% CI 2.3-20, P = 0.001) and 25-year FU (HR 3.0, 95% CI 1.1-7.8, P = 0.03).
|
30796653 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, inhibition of SRC-3 using either shRNA or a small molecule inhibitor can significantly inhibit tumor growth in orthotopic pancreatic cancer mouse models.
|
30423406 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have discovered a novel role of MAD2L2 in the regulation of NCOA3 degradation and proposed that MAD2L2 serves as a tumor suppressor in CRC.
|
29360267 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In line with previous studies, AIB1 correlated to a more aggressive tumor-phenotype (HER2 amplification and a high malignancy grade).
|
28766132 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To validate this result in vivo, we knocked down SRC3 expression in BMSCs in nude mice and found that tumor growth and cell apoptosis were significantly decreased.
|
29075794 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SRC-3 is widely expressed in multiple tumor types and involved in cancer cell proliferation and apoptosis.
|
27425252 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ANOVA analysis allowed to identify specific H3 signatures according to three groups of genes: hormonal receptor genes (ERS1, ERS2, PGR), genes modifying histones (EZH2, P300, SRC3) and tumor suppressor gene (BRCA1).
|
27424567 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry analysis in tumor tissues from patients and spontaneous mouse models, and microarray analysis following the knockdown of NCOA3 were performed to elucidate its role in mucin regulation and overall impact on PC.
|
25531332 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knockdown of SRC-3 reduced the UBC cell glycolytic rate under hypoxia, decreased tumor growth in nude mice, with reduction of proliferating cell nuclear antigen and lactate dehydrogenase expression levels.
|
24584933 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AIB1 protein expression was analysed by immunohistochemistry on tissue micro-arrays with tumour samples from 910 postmenopausal women randomised to tamoxifen treatment or no adjuvant treatment.
|
23670096 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AIB1 expression was detected in 60 % of the tumors.
|
23322234 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Because of SRC-3's ability to abrogate p53 function, our results suggest that SRC-3 overexpression may be especially important in tumors in which p53 is not mutated.
|
23388826 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We recently demonstrated that the E3 ubiquitin ligase adaptor speckle-type poxvirus and zinc finger (POZ) domain protein (SPOP) interacts directly with SRC-3 and promotes its cullin 3-dependent ubiquitination and proteolysis in breast cancer, thus functioning as a potential tumor suppressor.
|
23559371 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The steroid hormone receptor coactivator, Taiman (a homologue of SRC3/AIB1), is known to associate with Abrupt, and Taiman overexpression also drives tumour formation in cooperation with the loss of Scrib.
|
23874226 |
2013 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
SRC-3 deletion impaired cellular proliferation and reduced tumor size.
|
23650284 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, knockdown of ERK3 or SRC-3 inhibited the ability of lung cancer cells to invade and form tumors in the lung in a xenograft mouse model.
|
22505454 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SRC-3/AIB1 protein was also higher in tamoxifen treated tumors.
|
22703232 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although SRC-3's proliferative role in primary tumor formation in the mammary gland is well established, a role for this oncogenic coregulator in tumor cell motility and invasion has only recently been elucidated.
|
21047941 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IHC analysis detected AIB1 positivity in 47.3% of tumors, which did not correlate with AIB1 mRNA expression (p = 0.24, r = 0.10).
|
22035181 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, an SRC-3 transgenic mice model shows that SRC-3 induces tumors in several mouse tissues.
|
21647249 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Collectively, our results reveal DRO1 as an AIB1-targeted tumor suppressor, providing a novel mechanism for AIB1-dependent inhibition of apoptosis.
|
21871888 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Conversely, p68 shows no association with relapse-free period, or overall survival, but it is associated with an increased expression of Her2 (P=0.001), AIB-1 (P<0.001) and higher tumour grade (P=0.044).
|
19718048 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The recipient mice with transplanted AIB1(-/-)/PyMT tumors also had much less lung metastasis than the recipient mice with transplanted WT/PyMT tumors.
|
18644862 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Co-factor ACTR is frequently overexpressed and/or amplified in multiple types of tumors.
|
16921507 |
2006 |