CANX, calnexin, 821

N. diseases: 82; N. variants: 5
Disease: Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever 		0.010 Biomarker phenotype BEFREE Here we show that calnexin, a molecular chaperone located in the endoplasmic reticulum (ER), plays an important role in regulating the cytosolic free calcium concentration ([Ca<sup>2+</sup>]<sub>c</sub>) in <i>Aspergillus nidulans</i> Inactivation of calnexin (ClxA) in <i>A. nidulans</i> caused severe defects in hyphal growth and conidiation under ER stress caused by the ER stress-inducing agent dithiothreitol (DTT) or high temperature. 28550061 2017