CAST, calpastatin, 831

N. diseases: 141; N. variants: 31
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.030 AlteredExpression disease BEFREE In the first approach, a B16-F10 model of melanoma was developed in transgenic mice expressing high extracellular levels of calpastatin. 31425704 2020
CUI: C0025202
Disease: melanoma
melanoma 		0.030 Biomarker disease BEFREE Combination treatment of Calpain inhibitor I with MEKi Trametinib in different melanoma cells is more effective in reducing melanoma cell growth compared to treatment with Trametinib alone, suggesting that this combination may have a therapeutic potential in melanoma. 30131853 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.030 GeneticVariation disease BEFREE Formalin-fixed, paraffin-embedded melanoma samples were macrodissected before screening for mutations using Sanger sequencing, single-strand conformation analysis (SSCA), high resolution melting analysis (HRM) and competitive allele-specific TaqMan® PCR (CAST-PCR). 23584600 2013