CAST, calpastatin, 831

N. diseases: 141; N. variants: 31
Disease: Seizures ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures 		0.030 Biomarker phenotype BEFREE Finally, we checked the effect of a calpain inhibitor on seizure occurrence. 31495081 2019
CUI: C0036572
Disease: Seizures
Seizures 		0.030 GeneticVariation phenotype BEFREE Our results showed that: (1) Blockade of calpain by non-selective calpain inhibitor MDL-28170 prevented convulsant stimulation induced KCC2 downregulation, and reduced the incidence and the severity of pentylenetetrazole (PTZ) induced seizures. 30186110 2018
CUI: C0036572
Disease: Seizures
Seizures 		0.030 Biomarker phenotype BEFREE A calpain inhibitor ameliorates seizure burden in an experimental model of temporal lobe epilepsy. 28237317 2017