AXIN2, axin 2, 8313

N. diseases: 169; N. variants: 34
Disease: Uranostaphyloschisis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.030 AlteredExpression disease BEFREE We found that cleft palate pathogenesis in Pax9-deficient embryos is accompanied by significantly reduced expression of Axin2, an endogenous target of canonical Wnt signaling, in the developing palatal mesenchyme, particularly in the posterior regions of the palatal shelves. 28692808 2017
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.030 Biomarker disease BEFREE Comparison between cleft and control groups showed a trend for association for AXIN2 with incomplete cleft palate (p = .006) and CDH1 with unilateral CL/P (p = .03 for left CL/P and p = .04 for right CL/P). 18683894 2009
CUI: C2981150
Disease: Uranostaphyloschisis
Uranostaphyloschisis 		0.030 GeneticVariation disease BEFREE Some genes affecting early tooth development (MSX1, AXIN2) are associated with tooth agenesis and systemic features (cleft palate, colorectal cancer). 18499550 2008