FZD4, frizzled class receptor 4, 8322

N. diseases: 239; N. variants: 28
Disease: Agnosia for Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		0.020 Biomarker disease BEFREE This finding further consolidates the pharmacological targeting of GPCRs by hemorphins as previously shown for the opioid receptors in analgesia opening a new era for investigating the role of hemorphins in physiology and pathophysiology <i>via</i> the targeting of GPCR pharmacology and signaling. 31708782 2019
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		0.020 GeneticVariation disease BEFREE These results suggest a new molecular mechanism for CCK-8 antagonism to opioid analgesia in terms of G-protein-coupled receptor (GPCR) interaction through direct heteromerization. 29780163 2018