FZD6, frizzled class receptor 6, 8323

N. diseases: 57; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085661
Disease: Onycholysis
Onycholysis 		0.110 GeneticVariation disease BEFREE Inherited isolated nail anomaly manifesting with onychauxis and onycholysis is a rare condition, caused by mutations in the gene FZD6, encoding membrane-bound Wnt receptor protein. 22861124 2013
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE The molecular mechanism of nail (and claw) development is largely unknown, but we have recently identified a Wnt receptor gene, Frizzled6 (Fzd6), that is mutated in a human autosomal-recessive nail dysplasia. 23439395 2013
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE We identified a homozygous deletion mutation in FZD6 in a consanguineous Turkish family with nail dysplasia. 30642273 2019
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE Few case reports have identified mutations in the Frizzled 6 (<i>FZD6</i>) gene in families presenting with abnormal nails consistent with Non-Syndromic Congenital Nail Dysplasia. 31497560 2019
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE To search for sequence variants in the gene FZD6 in three individuals of a consanguineous family exhibiting features of nail dysplasia. 22861124 2013
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a large Iranian kindred. 28545862 2017
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE Only recently, FZD6 mutations were identified in isolated nail dysplasia. 22211385 2012
CUI: C1834405
Disease: Nail dysplasia
Nail dysplasia 		0.070 GeneticVariation disease BEFREE Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. 21665003 2011
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE To search for sequence variants in the gene FZD6 in three individuals of a consanguineous family exhibiting features of nail dysplasia. 22861124 2013
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE Only recently, FZD6 mutations were identified in isolated nail dysplasia. 22211385 2012
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE A novel pathogenic variant in the FZD6 gene causes recessive nail dysplasia in a large Iranian kindred. 28545862 2017
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE Mutations in Frizzled 6 cause isolated autosomal-recessive nail dysplasia. 21665003 2011
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE Few case reports have identified mutations in the Frizzled 6 (<i>FZD6</i>) gene in families presenting with abnormal nails consistent with Non-Syndromic Congenital Nail Dysplasia. 31497560 2019
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE We identified a homozygous deletion mutation in FZD6 in a consanguineous Turkish family with nail dysplasia. 30642273 2019
CUI: C3279947
Disease: NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9
NAIL DISORDER, NONSYNDROMIC CONGENITAL, 9 		0.070 GeneticVariation disease BEFREE The molecular mechanism of nail (and claw) development is largely unknown, but we have recently identified a Wnt receptor gene, Frizzled6 (Fzd6), that is mutated in a human autosomal-recessive nail dysplasia. 23439395 2013
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE The function played by Fzd6 in the physiology of normal and cancer cells has been highlighted in the view that an increased knowledge of the signalling pathways upstream and downstream of this receptor could ultimately result in the identification of new targets for cancer therapy. 28737757 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway. 31814913 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 AlteredExpression group BEFREE Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development. 25772759 2015
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE In xenograft studies, tumors with autocrine hGH expressed higher levels of WNT4 and FZD6 when compared with control tumors. 27323961 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE Multivariate analysis indicated an independent prognostic significance of FZD6 expression in TNBC tumours, predicting distant, but not local, relapse. 27859262 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Furthermore, we identified FZD6 as a tumor suppressor that can abolish PCa stemness. 29867083 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 AlteredExpression group BEFREE Among the members of the FZD family, FZD6 is broadly expressed in various tissues, and its overexpression has been reported in several cancers, suggesting an important role in cancer development. 25772759 2015
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE lncRNA PCAT-1 interacting with FZD6 contributes to the malignancy of acute myeloid leukemia cells through activating Wnt/β-catenin signaling pathway. 31814913 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE The function played by Fzd6 in the physiology of normal and cancer cells has been highlighted in the view that an increased knowledge of the signalling pathways upstream and downstream of this receptor could ultimately result in the identification of new targets for cancer therapy. 28737757 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.020 AlteredExpression disease BEFREE Knockdown of FZD6 expression with a small-interfering RNA almost completely reversed the proliferative effects of NPTX2 on CRC development. 30833544 2019