|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that overexpression of FZD6, mediated by reduced expression of miR-199a-5p, may play an important role in the development of CRC.
|
25772759 |
2015 |
|
Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
|
27698350 |
2016 |
|
Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among all data sets, color deconvolution (A) demonstrated the most preferable fit in a proportional hazard model, and the expression of Fzd2 and Fzd6 was associated with poor prognosis in glioblastoma patients.
|
23748645 |
2014 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Frizzled-6 protein expression was analyzed in 30 LMS (15 primary, 15 metastases).
|
26768834 |
2016 |
|
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, NPTX2, a molecule related to nervous system diseases, promotes CRC cell proliferation and metastasis through the activation of the Wnt/β-catenin pathway via direct interaction with FZD6.
|
30833544 |
2019 |
|
Neural Tube Defects
|
0.020 |
GeneticVariation
|
group |
BEFREE |
This study demonstrates that rare nonsynonymous variants in FZD6 may contribute to NTDs in humans and enlarges the spectrum of mutations that link PCP pathway to NTDs.
|
22045688 |
2012 |
|
Neural Tube Defects
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The rs3808553 of FZD6 is obviously associated with NTDs in Han population of northern China.
|
24816679 |
2014 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
|
27698350 |
2016 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among all data sets, color deconvolution (A) demonstrated the most preferable fit in a proportional hazard model, and the expression of Fzd2 and Fzd6 was associated with poor prognosis in glioblastoma patients.
|
23748645 |
2014 |
|
Childhood Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among all data sets, color deconvolution (A) demonstrated the most preferable fit in a proportional hazard model, and the expression of Fzd2 and Fzd6 was associated with poor prognosis in glioblastoma patients.
|
23748645 |
2014 |
|
Childhood Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
|
27698350 |
2016 |
|
Papillary craniopharyngioma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage.
|
28737757 |
2017 |
|
Papillary craniopharyngioma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these results showed that FZD6 abundance in the villus was higher than that in crypt cells and knockdown of FZD6 induces PCP signal pathway components expression in IPEC-J2 cells.
|
28614361 |
2017 |
|
Nail abnormality
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Few case reports have identified mutations in the Frizzled 6 (<i>FZD6</i>) gene in families presenting with abnormal nails consistent with Non-Syndromic Congenital Nail Dysplasia.
|
31497560 |
2019 |
|
Nail abnormality
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
A few case reports have identified mutations in the Frizzled 6 (FZD6) gene in families presenting with abnormal nails consistent with IRND.
|
27786367 |
2016 |
|
Pneumocystis jiroveci pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-canonical WNT/PCP signalling in cancer: Fzd6 takes centre stage.
|
28737757 |
2017 |
|
Pneumocystis jiroveci pneumonia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these results showed that FZD6 abundance in the villus was higher than that in crypt cells and knockdown of FZD6 induces PCP signal pathway components expression in IPEC-J2 cells.
|
28614361 |
2017 |
|
Glioblastoma Multiforme
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Among all data sets, color deconvolution (A) demonstrated the most preferable fit in a proportional hazard model, and the expression of Fzd2 and Fzd6 was associated with poor prognosis in glioblastoma patients.
|
23748645 |
2014 |
|
Glioblastoma Multiforme
|
0.020 |
Biomarker
|
disease |
BEFREE |
A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways.
|
27698350 |
2016 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Fzd6 was widely expressed in GHomas, PRLomas, TSHomas, and gonadotropin subunit (GnSU)-positive adenomas.
|
19034702 |
2008 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the FZD6-fibronectin actin axis identified in our study could be exploited for drug development in highly metastatic forms of breast cancer, such as TNBC.© 2016 The Authors.
|
27859262 |
2017 |
|
Malignant neoplasm of endometrium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By co-culture IP assay, we demonstrated that SMOC-2 directly interacted with WNT receptors (Fzd6 and LRP6), enhanced ligand-receptor interaction with canonical WNT ligands (Wnt3a and Wnt10b), and finally, activated the WNT/β-catenin pathway in endometrial cancer.
|
30594556 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression.
|
21937024 |
2012 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Analysis of target genes regulated by chronic electroconvulsive therapy reveals role for Fzd6 in depression.
|
21937024 |
2012 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elimination of Fzd6 expression by crossing into Fzd6(-/-) mice significantly delays development of chronic lymphocytic leukemia in this model.
|
19179304 |
2009 |