ELOVL3, ELOVL fatty acid elongase 3, 83401

N. diseases: 11; N. variants: 2
Disease: Dermatitis, Atopic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.020 AlteredExpression disease BEFREE RNA sequencing analysis performed on stratum corneum of AD as compared with healthy subjects identified decreased expression of fatty acid elongases ELOVL3 and ELOVL6 that contributed to observed changes in atopic skin lipids. 29467325 2018
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.020 Biomarker disease BEFREE We identified wide lipid abnormalities and, for the first time in vivo, correlated Th2 immune activation with downregulation of key epidermal lipids (FA2H, FAR2, ELOVL3), emphasizing the role of cytokines on the barrier disruption in AD. 26459294 2015