|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that the expression of ICE and CPP32 were down-regulated and that especially reduced expression of CPP32 may contribute to resistance against apoptosis in human HCCs.
|
10928128 |
2000 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
HBV-related HCC demonstrated significantly suppressed caspase-3 activity, signifying apoptosis.
|
12632104 |
2003 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
Parvovirus B19-induced apoptosis of hepatocytes.
|
15220451 |
2004 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Caspase-3 overexpression in HCCs by immunohistochemistry was associated with serum alpha-fetoprotein (AFP) levels (P=0.01).
|
15098015 |
2004 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Huh-7 human hepatoma tumor growth in nude mice with a defect of T cell function was significantly inhibited by Ad.PPThIL-18CPP32- compared with Ad.hProIL-18 encoding immature IL-18.
|
15044962 |
2004 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Apoptosis was selectively induced following infection of HuH7 cells with RevCasp3, demonstrating that retroviruses expressing RevCasp3 are of potential interest for the treatment of hepatocellular carcinomas and other tumour types.
|
15521050 |
2005 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interestingly, MK-AS also clearly downregulated the protein level of Bcl-2, and upregulated p53, Bax, and caspase-3 in the hepatocellular carcinoma tissue.
|
17303011 |
2007 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
Genetically distinct and clinically relevant classification of hepatocellular carcinoma: putative therapeutic targets.
|
17983802 |
2007 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results reveal that both methods are suitable and sensitive techniques for the in situ detection of apoptosis, however, they also demonstrate that immunohistochemistry for active caspase 3 and single-stranded DNA have differential sensitivities in HCC and CRC.
|
18027258 |
2007 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated that restoration of DLC1 tumor suppressor gene expression in the DLC1-negative Focus and 7703K human hepatocellular carcinoma (HCC) cell lines induced caspase-3 mediated apoptosis, reduced cell growth in vitro and tumorigenicity in vivo and diminished the ability to migrate through Matrigel, a property suggestive of metastatic potential in vivo.
|
18497990 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Lentiviral-mediated Smad4 RNAi induced anti-proliferation by p16 up-regulation and apoptosis by caspase 3 down-regulation in hepatoma SMMC-7721 cells.
|
18949401 |
2008 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Caspase-3 gene transfected with LIGHT gene: can it be used for therapy of human hepatocellular carcinoma?
|
18298346 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The analysis of HCC tissues revealed an inverse correlation between miR-221 and Bmf expression and a direct correlation between Bmf and activated caspase-3, as a marker of apoptosis.
|
19671867 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Effects of GTN were evaluated by the flow cytometry, alkaline comet assay, immunocytochemistry, small-hairpin RNA interference, mitochondria/cytosol fractionation, quantitative reverse transcription-polymerase chain reaction, immunoblotting analysis and caspase 3 activity assays in two HCC-derived cell lines.
|
21810437 |
2011 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Nuclear expression of TG2 and crosslinked Sp1, as also activated caspase 3 were found in both hepatocellular carcinoma cells transplanted into nude mice and cancerous regions within the liver in N-diethylnitrosamine-induced hepatocarcinogenesis model in rats, following treatment of animals with acyclic retinoid.
|
21214951 |
2011 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of mfn2 inhibited HCC cell proliferation and induced apoptosis by increasing the level of active caspase-3 and poly (ADP-ribose) polymerase (PARP) cleavage.
|
21190094 |
2012 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PCNA was co-localized with active caspase 3 protein expression in HBx zebrafish liver samples and human HBV positive HCC samples by double fluorescence immunostaining.
|
23499292 |
2013 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The induction of HCC cell apoptosis by UDCA was dose-dependent and time-dependent and was mediated by the regulation of Bax to Bcl-2 ratio, the expressions of Smac and Livin, and caspase-3 expression and activity.
|
25214410 |
2014 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
In contrast, here we demonstrated apoptosis induction in human lung epithelial carcinoma (A549), human hepatocarcinoma and Vero cells upon infection with the attenuated Candid#1 strain of, JUNV as determined by phosphatidylserine (PS) translocation, Caspase 3 (CASP3) activation, Poly (ADP-ribose) polymerase (PARP) cleavage and/or chromosomal DNA fragmentation.
|
24918927 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that gene expression of caspase 3, P21 and P53 was significantly upregulated, whereas gene expression of Bcl-2 and survivin was downregulated in the HCC groups after MSC injection.
|
24985939 |
2014 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Further studies also indicated that SEPT2 promoted HCC cell growth via upregulation of matrix metalloproteinase (MMP)-2 and -9, and simultaneously inhibited the cleavage of caspase-3, -7, and -9.
|
25592041 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
MiR-30a-5p mimic markedly inhibited cell growth, also induced caspase-3/7 activity and apoptosis in all four HCC cell lines tested.
|
26884832 |
2015 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, downregulation of PHLDA gene, upregulation of ACIN1 protein and caspase-3 activation in exposed cells indicated that endosulfan can trigger apoptotic cascade in hepatocellular carcinoma cells.
|
26615145 |
2015 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The present study shows that lupeol can inhibit cell proliferation of hepatocellular carcinoma (HCC) HCCLM3 cells in a time- and dose-dependent manner, through caspase-3 dependent activation and Poly ADP-Ribose Polymerase (PARP) cleavage.
|
26004524 |
2015 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
miR-193b acts as a cisplatin sensitizer via the caspase-3-dependent pathway in HCC chemotherapy.
|
25997995 |
2015 |