Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of mTOR signaling and caspase-3 in tivantinib-treated glioblastoma cells was differentially measured by western blotting.
|
31575848 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The higher expression of LINC-ROR was associated with poor disease progression-free and overall survival as well as a younger age of patients ( P=0.036). p53 protein was expressed only in glioblastoma but not in non-cancer tissues while caspase 3 was weakly expressed in most non-cancer tissues and in varying degrees in glioblastoma (24% weak, 30% moderate, and 16% strong expression).
|
30852975 |
2019 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Isolinderalactone regulates the BCL-2/caspase-3/PARP pathway and suppresses tumor growth in a human glioblastoma multiforme xenograft mouse model.
|
30503550 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Resveratrol and siRNA in combination reduces Hsp27 expression and induces caspase-3 activity in human glioblastoma cells.
|
31073903 |
2019 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, NK-EM cytotoxicity for glioblastoma cells that related with decreased levels of the cell survival markers p-ERK and p-AKT, and increased levels of apoptosis protein markers cleaved-caspase 3, cytochrome-c and cleaved-PARP was confirmed.
|
30092165 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel nanocomposite based on fluorescent turn-on gold nanostars for near-infrared photothermal therapy and self-theranostic caspase-3 imaging of glioblastoma tumor cell.
|
29936383 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that this molecule exerts its cytotoxicity via caspase 3/7 independent pathways in glioblastoma cells.
|
30179612 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Western blot analysis also indicated that TMZ but not DMC more significantly decreased p-Akt and increased cleaved-caspase-3 and Bax expression.These findings suggested a fact that TMZ appear to be more effective in controlling the growth of glioblastoma than DMC in an orthotopic glioblastoma xenograft model.
|
29575236 |
2018 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This CTRP8 effect was independent of cellular MGMT levels and was associated with decreased caspase 3/7 activity and increased survival of human GBM.
|
29949238 |
2018 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the expression levels of the Bcl-2 anti-apoptotic protein was significantly decreased while Bax and caspase-3 expression were both increased in glioblastoma cells (all, p<0.05).
|
29940755 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The study shows NC employing pDok2, caspase 3 dependent cell death in C6 rat glioma and U87 human malignant glioblastoma cells.
|
29329030 |
2018 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using cell lines and online gene expression data, we identified procaspase-3 as a potential molecular target for most glioblastomas.
|
29113289 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to the apoptosis pathway were evaluated in 30 samples of glioblastoma.
|
29236891 |
2017 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bcl2L12 plays a role in post-mitochondrial apoptosis through multiple mechanisms involving p53, αB-crystallin, caspase-3 and -7 in glioblastoma.
|
26082034 |
2015 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study we investigated Bcl-6 translocation and its transcriptional and translational levels in formalin-fixed, paraffin-embedded cerebral tissue sections from glioblastoma (GBM), low-grade glioma (Astrocytoma grade II and III), and meningioma patients, and correlated them with apoptotic processes and p53 and caspase-3 expression.
|
25038272 |
2014 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that two candidate oncogenic microRNAs, miR-363 and miR-582-5p, can positively influence glioblastoma survival, as shown by forced expression of the microRNAs and their inhibitors followed by cell number assay, Caspase 3/7 assay, Annexin V apoptosis/fluorescence activated cell sorting, siRNA rescue of microRNA inhibitor treatment, as well as 3'UTR mutagenesis to show luciferase reporter rescue of the most successful targets. miR-582-5p and miR-363 are shown to directly target Caspase 3, Caspase 9, and Bim.
|
24805821 |
2014 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, we demonstrate that miR-30b/c and miR-21 target respectively the 3' untranslated region of caspase-3 and TAp63 mRNAs, and that those proteins mediate some of the effects of miR-30 and -21 on TRAIL resistance, even in human glioblastoma primary cells and in lung cancer cells.
|
22964638 |
2013 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Significant de-phosphorylation of Akt, increased Bax expression, decreased Bcl-2 expression and cleavage of caspase-3 were also observed in resveratrol-induced apoptosis in glioblastoma cells.
|
21743969 |
2011 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
LLL12 was found to inhibit STAT3 phosphorylation (tyrosine 705) and induce apoptosis as indicated by the increases of cleaved caspase-3 and poly (ADP-ribose) polymerase in various breast, pancreatic, and glioblastoma cancer cell lines expressing elevated levels of STAT3 phosphorylation.
|
20072652 |
2010 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small interfering RNA (siRNA)-mediated transcriptional knockdown of urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinase-9 (MMP-9), alone or in combination, inhibits uPAR and/or MMP-9 expression and induces apoptosis in the human glioblastoma xenograft cell lines 4910 and 5310. siRNA against uPAR (pU-Si), MMP-9 (pM-Si), or both (pUM-Si) induced apoptosis and was associated with the cleavage of caspase-8, caspase-3, and poly(ADP-ribose) polymerase.
|
20716639 |
2010 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma.
|
18669646 |
2008 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Immunohistochemistry showed that the glioblastoma xenografts contain cells positive for caspase-3, caspase-9, and Bax.
|
18814044 |
2008 |
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Basal caspase activity promotes migration and invasiveness in glioblastoma cells.
|
18171980 |
2007 |
Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The correction of FGFR1 gene splicing to >90% alpha-exon inclusion in glioblastoma cells had no discernable effect on cell growth in culture, but was associated with an increase in unstimulated caspase-3 and -7 activity.
|
15333583 |
2004 |
Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activation of caspase-1 and caspase-3 is observed also in neuroblastoma lines expressing other fALS-SOD1s (G37R, G85R, and I113T) cocultured with glioblastoma lines expressing the corresponding mutant enzymes.
|
15208263 |
2004 |