|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cardio-protective effect of the secretome of Sca-1+ and Sca-1- cells in heart failure - not equal, but equally important?
|
31119267 |
2020 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overall, these findings revealed global modifications in the secretory activity of adult Sca-1 <sup>+</sup> cells in the heart failure milieu.
|
30575044 |
2019 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
In LV tissues, protein expressions of inflammatory (tumor-necrosis factor-α/nuclear-factor-κB/interleukin-1ß/matrix-metalloprotianse-9), oxidative stress (NOX-1/NOX-2/oxidized protein), apoptotic (mitochondrial-Bax/cleaved-caspase-3/cleaved-PARP), fibrotic (transforming-growth factor-ß/Smad3), DNA/mitochondrial-damage (γ-H2AX/cytosolic-cytochrome-C) and heart failure (brain natriuretic peptide (BNP) levels displayed an opposite pattern to LVEF among the three groups (all p < 0.0001).
|
30404073 |
2019 |
|
Congestive heart failure
|
0.300 |
Therapeutic
|
disease |
RGD |
Shenfu Formula reduces cardiomyocyte apoptosis in heart failure rats by regulating microRNAs.
|
29746994 |
2018 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This study was designed to explore the variations in melatonin, myeloperoxidase, and caspase-3 levels in children suffering from heart failure.
|
29111293 |
2018 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Expression of CHRF and TGF-β1 was up-regulated, and cell apoptosis and caspase-3 activity were increased in the hearts and cells of the HF models.
|
29124661 |
2018 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In ISO-induced cardiac injury, shikonin significantly ameliorated heart function, decreased myocardial fibrosis, suppressed inflammation, attenuated apoptosis and ER stress through impeding collagen accumulation, Toll like receptor 4/nuclear transcription factor κB (TLR4/NF-κB), Caspase-3 and glucose-regulated protein 78 (GRP78) signaling pathways activity, relieving heart failure in vivo.
|
28753907 |
2017 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> Tand-scFv<sub>Sca-1+GPIIb/IIIa</sub> is a promising candidate to enhance therapeutic cell delivery in order to promote myocardial regeneration and thereby preventing heart failure.
|
28900504 |
2017 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of caspase‑3 and Bcl‑2‑associated X protein were decreased in the CHF‑VNS group, the expression of Birc2 and B‑cell lymphoma 2 were increased.
|
28849082 |
2017 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Comparative gene expression profiling of freshly isolated undifferentiated Sca-1 progenitor cells derived either from heart failure transgenic αMHC-CyclinT1/Gαq overexpressing mice or wildtype littermates revealed transcriptional variations.
|
25799225 |
2015 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Related mRNAs (casp3, coll I, coll III and TGF) were also significantly up-regulated (all p<0.05) in the heart failure group.
|
26188824 |
2015 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In vitro, cell viability, DNA fragmentation and caspase-3 levels were investigated in TECs incubated with HF, CRS1, and CTR plasma.
|
26228789 |
2015 |
|
Congestive heart failure
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Ingenuity Pathway Analysis indicated that cross-talk among several key nodal molecules (e.g. cyclin-dependent kinase inhibitor 1A, caspase-3, nuclear factor kappa-light-chain enhancer of activated B cells etc.) may play a regulatory role in the transition of CH to HF.
|
20202977 |
2010 |
|
Congestive heart failure
|
0.300 |
Biomarker
|
disease |
BEFREE |
Caspase 3 activation in heart failure sequentially cleaved SRF and generated a dominant-negative transcription factor, which may explain the depression of cardiac-specific genes.
|
12874181 |
2003 |