CASP3, caspase 3, 836

N. diseases: 722; N. variants: 20
Disease: Alexander Disease ×
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270726
Disease: Alexander Disease
Alexander Disease 		0.010 GeneticVariation disease BEFREE Alexander disease causing mutations in the C-terminal domain of GFAP are deleterious both to assembly and network formation with the potential to both activate caspase 3 and decrease cell viability. 21756903 2011