CASP3, caspase 3, 836

N. diseases: 819; N. variants: 26
Disease: Senile Plaques ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.040 Biomarker disease BEFREE The clinical examination of the brains of patients with AD has demonstrated that caspase-3 colocalizes with senile plaques. 27227450 2016
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.040 AlteredExpression disease BEFREE To assess whether mRNA levels of caspase-3, 7, 8 and 9 change in AD brain, and whether these changes correlate with neurofibrillary tangles, Abeta40 or Abeta42 protein levels or senile plaques, 25 AD and 21 non-demented control brains were examined. 16772874 2006
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.040 Biomarker disease BEFREE We report here that senile plaques and neurofibrillary tangles in the AD brain are not associated with caspase-3 activation. 10499444 1999
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.040 Biomarker disease BEFREE Caspase-3 is the predominant caspase involved in APP cleavage, consistent with its marked elevation in dying neurons of Alzheimer's disease brains and colocalization of its APP cleavage product with A beta in senile plaques. 10319819 1999