|
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
|
Platelet Component Distribution Width Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Among 225 participants with available Core-E2 sequence (ATAHC, n=113; HITS-p, n=90; and HITS-c, n=22), HCV genotype prevalence was: G1a: 38% (n=86), G1b: 5% (n=12), G2a: 1% (n=2), G2b: 5% (n=11), G3a: 48% (n=109), G6a: 1% (n=2) and G6l 1% (n=3).
|
26631810 |
2016 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, high-throughput sequencing and crosslinking immunoprecipitation (HITS-CLIP) experiments of human Argonaute (AGO) during HCV infection showed robust AGO binding on the HCV 5'UTR at known and predicted miR-122 sites.
|
25768906 |
2015 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Behavioural data and DNA from IDU (n = 210) in the Hepatitis C Incidence and Transmission Study in prisons (HITS-p) cohort were genotyped for polymorphisms in: IL-28B, peptidyl-prolyl isomerase A (PPIA), HLA-C and KIR2.
|
24612442 |
2014 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
FAM107B expression was decreased in stomach cancer and many other kinds of cancer.
|
28675500 |
2017 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
FAM107B expression was decreased in stomach cancer and many other kinds of cancer.
|
28675500 |
2017 |
|
Kaposi Sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
HITS-CLIP analysis uncovers a link between the Kaposi's sarcoma-associated herpesvirus ORF57 protein and host pre-mRNA metabolism.
|
25710169 |
2015 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
|
24906430 |
2014 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
|
24906430 |
2014 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In addition, effects of tetracycline-inducible HITS expression on tumor growth were investigated in vivo.
|
22825356 |
2012 |
|
Kaposi Sarcoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ago HITS-CLIP expands understanding of Kaposi's sarcoma-associated herpesvirus miRNA function in primary effusion lymphomas.
|
22927820 |
2012 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pharmacological agents that targeted the top scoring hits/genes from our RNAi screens were used in combination with paclitaxel, and the effects on the growth of various breast cancer cell lines were determined.
|
20576088 |
2010 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In the present study, we designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer.
|
20664927 |
2010 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus HITS would be a potential tumor suppressor gene similar to TU3A containing heat responding elements, which contrasts with previously described oncogenic activities of other heat shock proteins such as HSP70 and HSP90.
|
20664927 |
2010 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Pharmacological agents that targeted the top scoring hits/genes from our RNAi screens were used in combination with paclitaxel, and the effects on the growth of various breast cancer cell lines were determined.
|
20576088 |
2010 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In the present study, we designated FAM107B as heat shock-inducible tumor small protein (HITS) and studied its expression and functional properties in cancer.
|
20664927 |
2010 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
HITS were detected in 0%, 50%, and 90% of the animals at baseline and during AMI-1 and AMI-2 phases, respectively.
|
31813676 |
2020 |
|
Microembolus
|
0.010 |
Biomarker
|
disease |
BEFREE |
The residence time performed well to predict microemboli (C-index = 0.89, 95% CI, 0.75-1.00) and closely correlated with the number of HITS (R = 0.87, P < .001).
|
31813676 |
2020 |
|
Abetalipoproteinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Results of the screen showed that more than half of the hits targeted the Src/c-Abl signaling pathway.
|
28539470 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAM107B expression was decreased in stomach cancer and many other kinds of cancer.
|
28675500 |
2017 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
FAM107B expression was decreased in stomach cancer and many other kinds of cancer.
|
28675500 |
2017 |
|
Myotonic Dystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we use HITS-CLIP and pre-mRNA processing analysis of human control versus myotonic dystrophy (DM) brains to provide compelling evidence for this RNA toxicity model.
|
26257173 |
2015 |
|
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism.
|
24613350 |
2014 |
|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The HITS expression intensity was inversely correlated with the primary tumor size in breast and thyroid cancers.
|
22825356 |
2012 |