ANGPTL6, angiopoietin like 6, 83854

N. diseases: 48; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.110 Biomarker group HPO
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease HPO
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.100 Biomarker disease HPO
CUI: C0014068
Disease: Encephalomalacia
Encephalomalacia 		0.100 Biomarker disease HPO
CUI: C0018989
Disease: Hemiparesis
Hemiparesis 		0.100 Biomarker phenotype HPO
CUI: C0028866
Disease: Oculomotor Nerve Paralysis
Oculomotor Nerve Paralysis 		0.100 Biomarker disease HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.100 Biomarker disease HPO
CUI: C0340643
Disease: Dissection of aorta
Dissection of aorta 		0.100 Biomarker disease HPO
CUI: C1298820
Disease: Aneurysm of aortic root
Aneurysm of aortic root 		0.100 Biomarker disease HPO
CUI: C1850601
Disease: Abnormality of brainstem morphology
Abnormality of brainstem morphology 		0.100 Biomarker phenotype HPO
CUI: C2713497
Disease: Saccular Aneurysm
Saccular Aneurysm 		0.100 Biomarker disease HPO
CUI: C3887875
Disease: Visual field defects
Visual field defects 		0.100 Biomarker group HPO
CUI: C4022868
Disease: Abnormal circle of Willis morphology
Abnormal circle of Willis morphology 		0.100 Biomarker phenotype HPO
CUI: C0003125
Disease: Anorexia Nervosa
Anorexia Nervosa 		0.010 AlteredExpression disease BEFREE ANGPTL6 levels of AN patients were increased relative to the control group (68.6 ± 9.9 ng/ml) and decreased from 110.2 ± 13.3 to 73.6 ± 7.1 ng/ml (p = 0.004) after partial realimentation. 27135654 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE AGF support tumor growth and progression. 27419371 2017
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.010 Biomarker group BEFREE ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. 31146977 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.010 Biomarker group BEFREE ANGPTL6 promotes endothelial cell migration and tube formation, Moreover, ANGPTL6 knockdown inhibits cancer cell apoptosis and invasiveness. 31146977 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE ANGPTL6 loss results in tumor growth in vivo. 31146977 2019
CUI: C0202230
Disease: Thyroid stimulating hormone measurement
Thyroid stimulating hormone measurement 		0.100 GeneticVariation phenotype GWASCAT A genome-wide association study identifies protein quantitative trait loci (pQTLs). 18464913 2008
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE Addition of exogenous miRNA-128 to CRL-1690 and CRL-2610 GBM cell lines (a) restored 'homeostatic' ARP5 (ANGPTL6), Bmi-1 and E2F-3a expression, and (b) significantly decreased the proliferation of CRL-1690 and CRL-2610 cell lines. 19941032 2010
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.020 Biomarker group BEFREE Although the physiologic functions of human AGF have not yet been identified, serum levels of AGF displayed up-regulation in groups with diseases including preeclampsia and diabetes; and there was little association between genetic variability of AGF and metabolic syndrome-related phenotypes. 20673930 2011
CUI: C0011847
Disease: Diabetes
Diabetes 		0.010 Biomarker disease BEFREE Although the physiologic functions of human AGF have not yet been identified, serum levels of AGF displayed up-regulation in groups with diseases including preeclampsia and diabetes; and there was little association between genetic variability of AGF and metabolic syndrome-related phenotypes. 20673930 2011
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.010 GeneticVariation disease BEFREE Altogether, our results indicate that rare coding variants in ANGPTL6 are causally related to familial forms of IA. 29304371 2018
CUI: C2945695
Disease: Limb ischemia
Limb ischemia 		0.020 AlteredExpression disease BEFREE Among LEPAD patients, those with critical limb ischemia (n=43) showed higher AGF levels (124.9±73.9 vs. 88.98±53.26ng/mL, P=0.01) compared with those with intermittent claudication (n=62). 27866700 2017