ANGPTL6, angiopoietin like 6, 83854

N. diseases: 48; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1862932
Disease: ANEURYSM, INTRACRANIAL BERRY, 1 (disorder)
ANEURYSM, INTRACRANIAL BERRY, 1 (disorder) 		0.300 GermlineCausalMutation disease ORPHANET Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm. 29304371 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.300 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker disease BEFREE Specially, bANGPTL6β gene probably contributes to a new target for treatment of obesity and obesity-related diseases. 31102716 2019
CUI: C0028754
Disease: Obesity
Obesity 		0.240 AlteredExpression disease BEFREE Since upregulation of ANGPTL6 is induced on metabolic stress, we investigated the hepatic expression of ANGPTL6 by leptin, a representative adipokine of obesity. 29852166 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.240 AlteredExpression disease BEFREE Baseline ANGPTL6 levels in patients with obesity and T2DM did not differ from the control group. 27135654 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.240 GeneticVariation disease BEFREE Further validation in cohorts with severe obesity and engineering the variants in model organisms will be needed to explore whether human variants in ANGPTL6 and other genes that lead to obesity when deleted in mice, do contribute to obesity. 28663568 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker disease MGD This study establishes AGF as a new hepatocyte-derived circulating factor that counteracts obesity and related insulin resistance. 15778720 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.110 Biomarker group BEFREE We observed a higher rate of individuals with a history of high blood pressure among affected versus healthy individuals carrying ANGPTL6 variants, suggesting that ANGPTL6 could trigger cerebrovascular lesions when combined with other risk factors such as hypertension. 29304371 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.110 Biomarker group HPO
CUI: C0202230
Disease: Thyroid stimulating hormone measurement
Thyroid stimulating hormone measurement 		0.100 GeneticVariation phenotype GWASCAT A genome-wide association study identifies protein quantitative trait loci (pQTLs). 18464913 2008
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease HPO
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.100 Biomarker disease HPO
CUI: C0014068
Disease: Encephalomalacia
Encephalomalacia 		0.100 Biomarker disease HPO
CUI: C0018989
Disease: Hemiparesis
Hemiparesis 		0.100 Biomarker phenotype HPO
CUI: C0028866
Disease: Oculomotor Nerve Paralysis
Oculomotor Nerve Paralysis 		0.100 Biomarker disease HPO
CUI: C0036572
Disease: Seizures
Seizures 		0.100 Biomarker phenotype HPO
CUI: C0038525
Disease: Subarachnoid Hemorrhage
Subarachnoid Hemorrhage 		0.100 Biomarker disease HPO
CUI: C0340643
Disease: Dissection of aorta
Dissection of aorta 		0.100 Biomarker disease HPO
CUI: C1298820
Disease: Aneurysm of aortic root
Aneurysm of aortic root 		0.100 Biomarker disease HPO
CUI: C1850601
Disease: Abnormality of brainstem morphology
Abnormality of brainstem morphology 		0.100 Biomarker phenotype HPO
CUI: C2713497
Disease: Saccular Aneurysm
Saccular Aneurysm 		0.100 Biomarker disease HPO
CUI: C3887875
Disease: Visual field defects
Visual field defects 		0.100 Biomarker group HPO
CUI: C4022868
Disease: Abnormal circle of Willis morphology
Abnormal circle of Willis morphology 		0.100 Biomarker phenotype HPO
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE ANGPTL6 loss results in tumor growth in vivo. 31146977 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE AGF support tumor growth and progression. 27419371 2017