CASP6, caspase 6, 839

N. diseases: 73; N. variants: 0
Disease: Impaired cognition ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE Therefore, methylene blue reverses Caspase-6-induced cognitive deficits by inhibiting Caspase-6, and Caspase-6-mediated neurodegeneration and neuroinflammation. 31843022 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE Our results suggest that full Casp6 activity may not be essential for healthy humans and support the use of Casp6 inhibitors against Casp6-dependent neurodegeneration in age-dependent cognitive impairment and AD. 29535332 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE The Caspase-6 expressing mice and control littermates were subjected to behavioral tests to assess Huntington disease-relevant psychiatric, motor, and cognitive deficits. 29352267 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.040 Biomarker disease BEFREE The effect of inhibitors on age-dependent cognitive deficits in Caspase-6 transgenic mice was assessed by the novel object recognition task. 28241839 2017