PLA2G10, phospholipase A2 group X, 8399

N. diseases: 86; N. variants: 0
Disease: Cholangitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008311
Disease: Cholangitis
Cholangitis 		0.010 Biomarker disease BEFREE In intrahepatic calculi, an enhanced expression of the sPLA2s and their possible cross-talk via sPLA2-receptor may be of pathophysiological significance for the chronic proliferative cholangitis, in association with the enhanced CFTR expression and the alterations in mucin gene expression in the bile ducts, probably through potentiating arachidonate metabolism with associated biliary alterations favoring growth of preexisting stones and even further progressions. 10094942 1999