Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4479322
Disease: ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE 		0.600 Biomarker disease GENOMICS_ENGLAND Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. 27049303 2016
CUI: C4479322
Disease: ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE 		0.600 GeneticVariation disease UNIPROT Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. 27049303 2016
CUI: C4479322
Disease: ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE
ECTODERMAL DYSPLASIA 13, HAIR/TOOTH TYPE 		0.600 Biomarker disease CTD_human
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. 20153141 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. 20153141 2010
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.110 GeneticVariation disease BEFREE Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. 27049303 2016
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.110 GeneticVariation disease BEFREE Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. 27049303 2016
CUI: C0020608
Disease: Hypodontia
Hypodontia 		0.110 Biomarker disease HPO
CUI: C4082304
Disease: Oligodontia
Oligodontia 		0.110 Biomarker disease HPO
CUI: C1842366
Disease: Low anterior hairline
Low anterior hairline 		0.100 Biomarker phenotype HPO
CUI: C1843300
Disease: Sparse eyelashes
Sparse eyelashes 		0.100 Biomarker phenotype HPO
CUI: C4281771
Disease: Thin eyebrow
Thin eyebrow 		0.100 Biomarker phenotype HPO
CUI: C0000846
Disease: Agenesis
Agenesis 		0.010 GeneticVariation disease BEFREE Novel variants in KREMEN1 were identified as likely pathogenic in 2 families with suspected syndromic tooth agenesis. 28813618 2018
CUI: C0014378
Disease: Enterovirus Infections
Enterovirus Infections 		0.010 Biomarker group BEFREE The atomic-resolution structure of the CVA10 virion, which is within the KREMEN1-dependent subgroup, shows significant conformational differences in the putative receptor binding sites and serotype-specific epitopes, when compared to the SCARB2-dependent subgroup of HEV-A, such as EV71, highlighting specific differences between the sub-groups. 30478256 2018
CUI: C0013575
Disease: Ectodermal Dysplasia
Ectodermal Dysplasia 		0.010 GeneticVariation disease BEFREE Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families. 27049303 2016
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation group BEFREE Finally, we show that somatic mutations of kremen1 found in human cancers can affect its pro-apoptotic activity, supporting a tumor suppressor function. 26206087 2016
CUI: C0175754
Disease: Agenesis of corpus callosum
Agenesis of corpus callosum 		0.010 GeneticVariation disease BEFREE These findings highlight the importance of Wnt pathway dysregulation in ACC and corroborate the finding of homozygous deletion of Wnt repressors ZNRF3 and KREMEN1. 25490274 2015
CUI: C0282160
Disease: Aplasia Cutis Congenita
Aplasia Cutis Congenita 		0.010 GeneticVariation disease BEFREE These findings highlight the importance of Wnt pathway dysregulation in ACC and corroborate the finding of homozygous deletion of Wnt repressors ZNRF3 and KREMEN1. 25490274 2015
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.010 Biomarker disease BEFREE KREMEN1 is associated with Wnt signalling pathway which has been shown to play an important role for neurodegeneration in Parkinson's disease. 25175702 2014
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.010 Biomarker disease BEFREE The inflammatory mediator, MMP3, was strongly upregulated (5-fold) in AS/SpA samples and the Wnt pathway inhibitors DKK3 (2.7-fold) and Kremen1 (1.5-fold) were downregulated. 24330574 2013
CUI: C0949690
Disease: Spondylarthritis
Spondylarthritis 		0.010 Biomarker disease BEFREE The inflammatory mediator, MMP3, was strongly upregulated (5-fold) in AS/SpA samples and the Wnt pathway inhibitors DKK3 (2.7-fold) and Kremen1 (1.5-fold) were downregulated. 24330574 2013
CUI: C0949691
Disease: Spondylarthropathies
Spondylarthropathies 		0.010 Biomarker group BEFREE The inflammatory mediator, MMP3, was strongly upregulated (5-fold) in AS/SpA samples and the Wnt pathway inhibitors DKK3 (2.7-fold) and Kremen1 (1.5-fold) were downregulated. 24330574 2013
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.010 AlteredExpression disease BEFREE CITED1 mRNA expression correlates with expression of CXXC4 and KREMEN1 in clinical hepatoblastoma specimens. 23308048 2012
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis 		0.010 Biomarker disease BEFREE Enhanced expression of DKK1 and DKK4 and KRM1 was detected in lung homogenates of IPF patients compared with transplant donors. 20650998 2011
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.010 Biomarker disease BEFREE The mRNA expression levels of DKK-1 binding receptor LRP5/6 and Krm1/2 in SCs from patients with MM were significantly higher than those in myeloma cells and in SCs from healthy donors. 20846389 2010