CASP7, caspase 7, 840

N. diseases: 83; N. variants: 16
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Therapeutic phenotype RGD Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway. 29538428 2018
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.500 Biomarker phenotype CTD_human Minocycline inhibits caspase activation and reactivation, increases the ratio of XIAP to smac/DIABLO, and reduces the mitochondrial leakage of cytochrome C and smac/DIABLO. 14998631 2004
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.400 GeneticVariation disease GWASCAT Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants. 27723757 2016
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.400 GeneticVariation disease GWASCAT Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.400 Biomarker disease CTD_human Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
CUI: C0042900
Disease: Vitiligo
Vitiligo 		0.400 GeneticVariation disease GWASDB Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. 22561518 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 Biomarker disease BEFREE Low BCL2 and low caspase-7 are highly prognostic of unfavourable outcome across all breast cancers. 30069746 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 AlteredExpression disease BEFREE Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. 21555521 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.320 Biomarker disease CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263 2006
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.310 AlteredExpression disease BEFREE Phosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell lines. 21555521 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.310 Biomarker disease CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263 2006
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C0026998
Disease: Acute Myeloid Leukemia, M1
Acute Myeloid Leukemia, M1 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.300 Biomarker disease CTD_human Discovery of epigenetically silenced genes in acute myeloid leukemias. 17330099 2007
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.300 Biomarker group CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263 2006
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker disease CTD_human Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. 16583263 2006
CUI: C0029866
Disease: Other ureteric obstruction
Other ureteric obstruction 		0.200 Therapeutic phenotype RGD Hypochlorite modified albumins promote cell death in the tubule interstitium in rats via mitochondrial damage in obstructive nephropathy and the protective effects of antioxidant peptides. 29781318 2018
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker disease RGD Evaluation of apoptotic pathways in dorsal root ganglion neurons following peripheral nerve injury. 29659443 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.200 Therapeutic disease RGD Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis. 28456626 2017
CUI: C0014179
Disease: Endometritis
Endometritis 		0.200 Therapeutic disease RGD Selenium Plays a Protective Role in Staphylococcus aureus-Induced Endometritis in the Uterine Tissue of Rats. 26920733 2016
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Therapeutic phenotype RGD Pomegranate exerts chemoprevention of experimentally induced mammary tumorigenesis by suppression of cell proliferation and induction of apoptosis. 26699876 2016
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Therapeutic disease RGD Effect of carvedilol against myocardial injury due to ischemia-reperfusion of the brain in rats. 25872160 2015
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.200 Therapeutic disease RGD Protection effect of survivin protein overexpression on acute myocardial infarction in rats. 26550220 2015