|
Bipolar Disorder
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Quantitative methylation specific PCR (qMSP) was employed to assess methylation of DTNBP1 promoter CpGs flanking a SP1 binding site in the saliva of SCZ patients, their first-degree relatives and control subjects (30, 15, and 30/group, respectively) as well as in post-mortem brains of patients with SCZ and bipolar disorder (BD) versus controls (35/group). qRT-PCR was used to assess DTNBP1 expression.
|
26285059 |
2015 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
The dysbindin-1 gene (DTNBP1) has been associated with schizophrenia and bipolar disorder diagnoses.
|
21305691 |
2011 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Genetic epidemiological studies support an overlap between schizophrenia and bipolar disorder, and COMT, BDNF, 5-HTT, NRG1 and DTNBP1 genes have been implicated in the aetiology of both these disorders.
|
19573260 |
2009 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene.
|
19089808 |
2009 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
BEFREE |
Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene.
|
19089808 |
2009 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
The dystrobrevin binding protein 1 (DTNBP1) and neuregulin 1 (NRG1) genes have been related to schizophrenia (SZ) and bipolar disorder (BP) by several whole-genome linkage and associations studies.
|
18234478 |
2008 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
PSYGENET |
Among 3 genes associated with schizophrenia or bipolar disorder in multiple previous studies, including dysbindin (DTNBP1), neuregulin (NRG1), and disrupted-in-schizophrenia 1 (DISC1), only DISC1 showed evidence of association in this cohort.
|
18180429 |
2008 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
BEFREE |
The dystrobrevin binding protein 1 (DTNBP1) and neuregulin 1 (NRG1) genes have been related to schizophrenia (SZ) and bipolar disorder (BP) by several whole-genome linkage and associations studies.
|
18234478 |
2008 |
|
Bipolar Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
We genotyped three single nucleotide polymorphisms of DTNBP1 (SNP A, P1763, and P1320) and analyzed the allele, genotype, and haplotype associations with bipolar disorder.
|
17433541 |
2007 |
|
Bipolar Disorder
|
0.380 |
GeneticVariation
|
disease |
BEFREE |
Single-nucleotide polymorphisms (SNPs) were genotyped in the DTNBP1 (dysbindin), G72/G30 and RGS4 genes, and the relatively unknown PIP5K2A gene, which is located in a region of linkage with both schizophrenia and bipolar disorder.
|
17410640 |
2007 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
BEFREE |
Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia.
|
16946192 |
2006 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
BEFREE |
They are consistent with the possibility that DTNBP1 influences susceptibility to a subset of bipolar disorder cases with psychosis.
|
15820225 |
2005 |
|
Bipolar Disorder
|
0.380 |
Biomarker
|
disease |
BEFREE |
Several disposition genes for schizophrenia (DTNBP1, NRG1, G72) were identified, whereas evidence for specific disposition genes in bipolar disorder is more limited.
|
14677079 |
2003 |