CASP8, caspase 8, 841

N. diseases: 480; N. variants: 32
Disease: Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.030 GeneticVariation group BEFREE We have analyzed the entire coding region of human CASPASE-8 gene for the detection of somatic mutations in 162 gastric carcinomas (40 early and 122 advanced cancers), 185 non-small cell lung cancers, 93 breast carcinomas, and 88 acute leukemias by PCR-single-strand conformation polymorphism. 15705878 2005
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.030 GeneticVariation group BEFREE The frequency of caspase-8 mutation in the carcinomas was significantly higher than that in adenomas (P < 0.05). 12949717 2003
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.030 AlteredExpression group BEFREE Both antiapoptotic genes such as FLIP and members of the Bcl-2 and IAP family as well as proapoptotic elements of the death receptor and mitochondrial apoptosis pathways were down-regulated in carcinomas resulting in a decreased activity of caspase-8, caspase-9, and caspase-3. 12810637 2003