|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukemia (APL) with transcripting three isoforms of mRNA from PML-RAR alpha fusion genes following renal transplantation has never been reported in the literature.
|
21269590 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
PML-RAR{alpha} and Dnmt3a1 cooperate in vivo to promote acute promyelocytic leukemia.
|
20861188 |
2010 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, Southeast Asian AML patients with a favorable karyotype including t(8;21)/AML-ETO, inv(16)(CBF beta/SMMHC), and t(15;17)/PML-RAR alpha were genotyped for KIT and FLT3 RTK mutations by PCR and sequencing.
|
18977345 |
2008 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
Biomarker
|
disease |
LHGDN |
Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR.
|
16502581 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
LHGDN |
Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR.
|
16502582 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The acute promyelocytic leukemia (APL)-associated fusion protein PML-retinoic acid receptor (RAR) behaves as an aberrant transcriptional repressor, due to its ability to induce chromatin modifications (histone deacetylation and DNA methylation) and silencing of PML-RAR target genes.
|
16449642 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transgenic mice expressing PML-RAR alpha develop APL with long latency, low penetrance, and acquired cytogenetic abnormalities.
|
16675706 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The analysis of experimental APL models (i.e., U937 cells engineered to express PML/RAR-Eo and NB4 cells) provided evidence that PML/RAR-Eo expression was associated with downmodulation of TRAIL-R1 and with resistance to TRAIL-mediated apoptosis.
|
15921376 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The PML/RAR oncogenic transcription factor is responsible for both the pathogenesis of APL and for its sensitivity to RA.
|
15735696 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PML/RAR alpha translocation in acute promyelocytic leukemia (APL) is an example where the resultant fusion protein recruits histone deacetylase complexes to target genes resulting in their inappropriate transcriptional repression.
|
15302897 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunophenotypic characteristics heretofore proclaimed as reliably characterizing APL (HLA-DR(low), CD34(low), P-glycoprotein(low) myeloid phenotype) do not differentiate from APL-like immune profiles unassociated with the PML/RAR alpha fusion transcript.
|
15108165 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relapse of APL was suspected at morphologic examination of the biopsy specimen of the ear mass, but t(15;17) and PML/RAR alpha rearrangement were not detected by chromosomal, fluorescence in situ hybridization (FISH), or reverse transcription polymerase chain reaction analysis of bone marrow samples.
|
15239396 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both the reduced baseline mobility of X-RAR alpha and the ligand-induced slowing of X-RAR alpha could be attributed to the protein interaction domain contained within X. RXR alpha aberrantly colocalized within each X-RAR alpha; colocalization of RXR alpha with promyelocytic leukemia (PML)-RAR alpha resulted in reduced mobility of RXR alpha.
|
15121864 |
2004 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PML-RAR alpha fusion protein is central to the pathogenesis of acute promyelocytic leukemia (APL).
|
12515727 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Quantitative real-time RT-PCR analysis of PML-RAR alpha mRNA in acute promyelocytic leukemia: assessment of prognostic significance in adult patients from intergroup protocol 0129.
|
12468436 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations indicate that PML/RAR alpha+ APL blasts are bipotent for differentiation through both neutrophilic and monocytic lineages, whereby monocytic differentiation is linked to c-fms expression and stimulation.
|
12529666 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The chimeric gene product PML-RAR alpha, the result of a reciprocal t(15;17) translocation, plays an important role in the pathogenesis of acute promyelocytic leukemia (APL).
|
12691149 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Even though it has been suggested that chromatin alteration is important for APL onset, the PML-RAR effect on chromatin of target promoters has not been investigated.
|
14612419 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results reveal new functions of PML and PML/RAR alpha and suggest that dysregulated STAT3 activity by PML/RAR alpha may participate in the pathogenesis of APL.
|
12506013 |
2003 |
|
Leukemia, Myelocytic, Acute
|
0.100 |
Biomarker
|
disease |
BEFREE |
FISH and RT-PCR were useful in detecting PML-RAR alpha fusion in cytogenetically normal patients and those in when karyotyping was a failure and can be used in routine analysis for rapid confirmation of t(15;17) in patients with acute myeloid leukaemia.
|
12138666 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of two atypical PML-RAR(alpha) transcripts in two patients with acute promyelocytic leukemia.
|
11916515 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy.
|
12032336 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of t(15;17) or PML-RAR alpha fusion transcript is the diagnostic hallmark of patients with acute promyelocytic leukaemia (APL).
|
12138666 |
2002 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(15;17)(q22;q21) translocation is tightly linked to the APL phenotype, and the resultant PML-RAR fusion can be demonstrated in 98% of APL cases.
|
12357344 |
2002 |
|
Neoplasm, Residual
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These results emphasize on the relevance of the correct identification of atypical PML-RAR(alpha) rearrangements because of the potential implications in leukemogenesis, in the response to treatment, and for the correct monitoring of minimal residual disease.
|
11916515 |
2002 |