Disease: Chikungunya Fever ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Lack of nsP2-specific nuclear functions attenuates chikungunya virus replication both in vitro and in vivo. 31163352 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE A strong polar interaction was predicted between Thr-180 (within the phosphorylation lip) of p38 and Gln-273 of nsP2, whereas, no such polar interaction was predicted for the phosphorylation lip of JNK which indicates the differential roles of p-p38 and p-JNK during CHIKV infection in the host macrophages. 31031770 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Chikungunya virus (CHIKV) is a highly pathogenic alphavirus representative, and its nonstructural protein 2 (nsP2) plays critical roles in both inhibition of transcription and CPE development. 30487275 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase. 31000599 2019
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 AlteredExpression disease BEFREE Chikungunya virus nsP1 interacts directly with nsP2 and modulates its ATPase activity. 29348627 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE These results suggest that UBE2L3 is a cellular target of the CHIKV nsP2 protease, and this possibly mediates the pathogenesis of chikungunya fever. 28975709 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE This demonstrates that the C-terminal domain of nuclear nsP2 specifically inhibits the IFN response by promoting the nuclear export of STAT1.<b>IMPORTANCE</b> Chikungunya virus is an emerging pathogen associated with large outbreaks on the African, Asian, European, and both American continents. 29925658 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 AlteredExpression disease BEFREE In the present study, a FRET based protease assay was used to analyze the proteolytic activity of chikungunya nsP2 protease (CHIKV nsP2pro) - an essential viral enzyme, with fluorogenic substrate peptide. 29635044 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Development of nsP2 protease based cell free high throughput screening assay for evaluation of inhibitors against emerging Chikungunya virus. 30018455 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Crystal structure of chikungunya virus nsP2 cysteine protease reveals a putative flexible loop blocking its active site. 29730006 2018
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 AlteredExpression disease BEFREE Glutathionylation of chikungunya nsP2 protein affects protease activity. 27984114 2017
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE The N-terminal segment of papain is structurally identical with the Chikungunya virus-nsP2 protease. 28054451 2017
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Conformer and pharmacophore based identification of peptidomimetic inhibitors of chikungunya virus nsP2 protease. 27844505 2017
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.100 Biomarker disease BEFREE Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component. 22258240 2012