Reported herein is a programmed release nanoplatform of DHA to synergistically treat cancer with a Fe-TCPP [(4,4,4,4-(porphine-5,10,15,20-tetrayl) tetrakis(benzoic acid)] NMOF (nanoscale MOF) having a CaCO<sub>3</sub> mineralized coating, which prevents DHA leakage during transport in the bloodstream.
To overcome these shortcomings, herein, ultrasmall porphyrinic metal-organic framework nanodots (MOF QDs) prepared from NMOFs are rationally synthesized <i>via</i> a facile method and used as renal-clearable nanoagents for the enhanced PDT of cancer.
The proposed strategy for developing CDs@ZrHf-MOF-based aptasensor is promising for the early and sensitive detection of cancer markers and living cancer cells.
Here, for the first time, we demonstrated that a novel mixed-metal metal-organic framework nanoparticle (MOF NP) photosensitizer can be activated by a hydrogen sulfide (H<sub>2</sub> S) signaling molecule in a specific tumor microenvironment for PDT against cancer with controllable singlet-oxygen release in living cells.
These results suggest that MOF@HA@ICG NPs could be served as a new promising theranostic nanoplatform for improved anticancer PTT through cancer-specific and image-guided drug delivery.