ANTXR1, ANTXR cell adhesion molecule 1, 84168

N. diseases: 137; N. variants: 22
Disease: Anthrax disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 GeneticVariation disease BEFREE A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis. 29436111 2018
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Effects from metal ion in tumor endothelial marker 8 and anthrax protective antigen: BioLayer Interferometry experiment and molecular dynamics simulation study. 28437008 2017
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 AlteredExpression disease BEFREE Anthrax toxin receptor 1/tumor endothelial marker 8 (Antxr1 or TEM8) is up-regulated in tumor vasculature and serves as a receptor for anthrax toxin, but its physiologic function is unclear. 26785120 2016
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 GeneticVariation disease BEFREE An intronic single nucleotide polymorphism (SNP) in ANTXR1, an anthrax toxin receptor (chromosome 2p13), was associated with HbF. 27501013 2016
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Anthrax toxins enter cells via two identified anthrax toxin receptors: tumor endothelial marker 8 (TEM8) and capillary morphogenesis protein 2 (CMG2). 24742682 2014
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 AlteredExpression disease BEFREE Exposure to anthrax toxin alters human leucocyte expression of anthrax toxin receptor 1. 23607659 2013
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Furthermore, antibodies developed against the TEM8 extracellular domain blocked anthrax intoxication, inhibited tumor-induced angiogenesis, displayed broad antitumor activity, and augmented the activity of clinically approved anticancer agents without added toxicity. 22340594 2012
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Anthrax toxin acts by a sequence of events that begins when the protective-antigen (PA) moiety of the toxin binds to either one of two cell-surface proteins, ANTXR1 and ANTXR2, and is proteolytically activated. 22550037 2012
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE To explore whether proteins other than TEM8 and CMG2 function as anthrax toxin receptors in vivo, we challenged mice lacking TEM8 and/or CMG2. 23271637 2012
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE The anthrax toxin receptors tumor endothelial marker-8 (TEM-8) and capillary morphogenesis gene-2 (CMG-2) are responsible for allowing entry of anthrax toxin into host cells. 21196249 2011
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Bacillus anthracis protective antigen (PA), the B subunit of the binary anthrax toxin, binds to the cellular receptors capillary morphogenesis gene 2 protein and tumor endothelial marker 8 with high affinity. 17942931 2007
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease BEFREE Moreover, we observed efficient PA-mediated uptake into anthrax toxin receptor (ANTXR)-deficient Chinese hamster ovary cells (PR230) that had been stably engineered to express either human ANTXR1 or human ANTXR2 in the presence or absence of siRNA specific for LRP5 or LRP6. 17335347 2007
CUI: C0003175
Disease: Anthrax disease
Anthrax disease 		0.100 Biomarker disease LHGDN These results suggest that the ATR/TEM8 expression pattern that we describe here is highly relevant for understanding the pathogenesis of anthrax infection. 15689409 2005