|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, RECK-knockdowned cells showed higher cell viability and abilities of invasion/migration, indicating that RECK might be a tumor suppressor for tumor progression in oral cancer.
|
31618798 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we evaluated that the methylation degree of RECK was much higher in WT than in adjacent non-tumor tissues.
|
30841433 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Highlights ALK restrains cell growth, migration and invasion in OSCC cells; miR-9 is enhanced in OSCC tissues but is repressed by ALK in OSCC cells; miR-9 inverts the repressive effect of ALK on CAL-27 and SCC-9 cells; RECK is a novel target of miR-9; ALK or RECK hinders JAK1/STAT3 and PI3K/AKT pathways in CAL-27 and SCC-9 cells; ALK prohibits tumour formation <i>in vivo</i>.
|
31349748 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The reversion-inducing cysteine-rich protein with kazal motifs (RECK) gene was described as a tumor suppressor gene two decades ago.
|
31764436 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Additionally, proliferation, migration and invasion of glioma cells and tumor formation in nude mice were repressed owing to reduced expression of miR-30b-3p or elevated expression of RECK.
|
31270250 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
miR-15b-5p facilitates the tumorigenicity by targeting RECK and predicts tumour recurrence in prostate cancer.
|
29363862 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that a shorter isoform of RECK is more highly expressed in proliferating fibroblasts, in TGF-β-treated fibroblasts, and in tumors compared with differentiated tissue.
|
29874120 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a novel tumor suppressor gene that is critical for regulating tumor cell invasion and metastasis.
|
29510387 |
2018 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ameloblastomas were surgically removed from 30 patients and part of the tumor specimens were used to detect RECK gene polymorphisms by using PCR-single-strand conformation polymorphism (PCR-SSCP) and DNA sequencing analysis.
|
28340422 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HDAC Inhibitors and RECK Modulate Endoplasmic Reticulum Stress in Tumor Cells.
|
28134767 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA expression level of RECK was lower in ESCC tissues (mean<sub>-∆Cq</sub>=-4.66) compared with non-tumor tissues (mean<sub>-∆Cq</sub>=-2.79), and decreased RECK mRNA expression levels were associated with lymph node metastasis in ESCC.
|
28454343 |
2017 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This study aimed to investigate the role of tumor suppressor genes RASSF1A Ala133Ser and RECK rs11788747polymorphisms and their haplotypes in HCC.
|
26921475 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The levels of MMP-9 and RECK expression were analyzed by immunocytochemistry in liquid-based cytology samples from 136 women with high-grade cervical lesions (CIN2/CIN3) and cervical SCC diagnosed by LLETZ, and in 196 women without cervical neoplasia or CIN1.
|
26261088 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reversion‑inducing cysteine‑rich protein with Kazal motifs (RECK) is a novel tumour suppressor gene, which negatively regulates matrix metalloproteinases, and inhibits tumour invasion, angiogenesis and metastasis.
|
26299812 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A positive correlation has been observed between the abundance of RECK expression in tumor samples and a more favorable prognosis for patients with several types of tumors.
|
26431549 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reversion-inducing cysteine-rich protein with kazal motifs (RECK) is a membrane-anchored glycoprotein that negatively regulates the activity of MMPs, such as MMP-9 and MMP-2, which play a key role in the angiogenesis during tumor growth.
|
26004948 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reversion-inducing cysteine-rich protein with kazal motifs (RECK), a novel tumor suppressor gene that negatively regulates matrix metalloproteinases (MMPs), is expressed in various normal human tissues but downregulated in several types of human tumors.
|
25517920 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RECK is, therefore, a potential tumor inhibitor but also a prognostic marker available at early clinical stages.
|
25075007 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
However, despite the wide implication of these MMPs in melanoma establishment and progression, the role of RECK in this type of tumor is still unknown.
|
24335752 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RECK functions as a tumor suppressor by inhibiting migration, invasion, and angiogenesis.
|
23881612 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) is a tumor suppressor that inhibits metastasis and angiogenesis.
|
24646032 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here we show that expression of the matrix metalloproteinase (MMP) inhibitor RECK is activated in the cultured tumor cell lines by transfection with dsRNA complementary to the promoter of the RECK gene, leading to suppression of the expression of MMPs and it inhibited tumor cell invasion.
|
24651481 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The 5-year survival rate for patients with strong RECK expression was significantly higher than that with weakly expressing tumors.
|
23679328 |
2013 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
In conclusion, determination of RECK promoter methylation status in tumor tissues may assist in the identification of patients who require aggressive postoperative intervention in order to improve prognosis.
|
23749490 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The membrane-anchored matrix metalloproteinase-regulator RECK is often downregulated in cancers; in some cases, a significant correlation between the level of residual RECK in resected tumors and patient survival has been noted.
|
22158033 |
2012 |