MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
BEFREE |
Megf10 regulation of myoblast function appears to be mediated at least in part via interactions with key components of the Notch signaling pathway, and defects in these interactions may contribute to the pathogenesis of EMARDD.
|
28498977 |
2017 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
UNIPROT |
Megf10 regulation of myoblast function appears to be mediated at least in part via interactions with key components of the Notch signaling pathway, and defects in these interactions may contribute to the pathogenesis of EMARDD.
|
28498977 |
2017 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
Megf10 regulation of myoblast function appears to be mediated at least in part via interactions with key components of the Notch signaling pathway, and defects in these interactions may contribute to the pathogenesis of EMARDD.
|
28498977 |
2017 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
We here present two Japanese patients with MEGF10 mutations: one with EMARDD phenotype who had a novel homozygous frameshift mutation, c.131_132del, and the other with the milder phenotype who harbored a compound heterozygous mutation, c.2981-2A > G, and a novel missense mutation, p.Cys810Tyr.
|
27460346 |
2016 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
UNIPROT |
Our studies reveal that Megf10 is a receptor for C1q and identify a novel role for Megf10 in clearance of apoptotic cells in the mammalian developing brain with potential relevance to EMARDD patients and other CNS disorders.
|
27170117 |
2016 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
BEFREE |
We here present two Japanese patients with MEGF10 mutations: one with EMARDD phenotype who had a novel homozygous frameshift mutation, c.131_132del, and the other with the milder phenotype who harbored a compound heterozygous mutation, c.2981-2A > G, and a novel missense mutation, p.Cys810Tyr.
|
27460346 |
2016 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
BEFREE |
Our studies reveal that Megf10 is a receptor for C1q and identify a novel role for Megf10 in clearance of apoptotic cells in the mammalian developing brain with potential relevance to EMARDD patients and other CNS disorders.
|
27170117 |
2016 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
By novel analysis of SNP array hybridization and exome sequence coverage, we diagnosed a 10-years old girl with EMARDD following identification of a novel homozygous deletion of exon 7 in MEGF10.
|
23453856 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
UNIPROT |
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy.
|
23954233 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
BEFREE |
By novel analysis of SNP array hybridization and exome sequence coverage, we diagnosed a 10-years old girl with EMARDD following identification of a novel homozygous deletion of exon 7 in MEGF10.
|
23453856 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GermlineCausalMutation
|
disease |
ORPHANET |
By novel analysis of SNP array hybridization and exome sequence coverage, we diagnosed a 10-years old girl with EMARDD following identification of a novel homozygous deletion of exon 7 in MEGF10.
|
23453856 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
CLINVAR |
Cysteine mutations cause defective tyrosine phosphorylation in MEGF10 myopathy.
|
23954233 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
CLINVAR |
By novel analysis of SNP array hybridization and exome sequence coverage, we diagnosed a 10-years old girl with EMARDD following identification of a novel homozygous deletion of exon 7 in MEGF10.
|
23453856 |
2013 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores.
|
22371254 |
2012 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores.
|
22371254 |
2012 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores.
|
22371254 |
2012 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
CLINVAR |
Mutations in the satellite cell gene MEGF10 cause a recessive congenital myopathy with minicores.
|
22371254 |
2012 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
|
22101682 |
2011 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
|
22101682 |
2011 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
|
22101682 |
2011 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
GeneticVariation
|
disease |
CLINVAR |
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
|
22101682 |
2011 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD).
|
22101682 |
2011 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
CLINGEN |
Megf10 regulates the progression of the satellite cell myogenic program.
|
18056409 |
2007 |
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
MYOPATHY, AREFLEXIA, RESPIRATORY DISTRESS, AND DYSPHAGIA, EARLY-ONSET
|
0.740 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|