|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOPX is involved in multiple organ development and acts as a tumor suppressor in various cancers.
|
31666923 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, HOPX acts as a tumour suppressor via the epigenetic regulation of SNAIL transcription, which provides a novel prognostic biomarker for NPC metastasis and therapeutic target for NPC treatment.
|
28146149 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOPX is thought as a tumor suppressor gene and its promoter methylation is the main mechanism of down-regulation.
|
27756570 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate that applying INSPIRE to nine ovarian cancer datasets leads to a new marker and potential driver of tumor-associated stroma, HOPX, followed by experimental validation.
|
27287041 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results demonstrate that HOPX functions as a tumour suppressor in HNSCC and suggest a central role for HOPX in suppressing epithelial carcinogenesis.
|
27934959 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It turned out that HOPX inhibited tumour cell proliferation rate, migration, and invasion, and, more interestingly, forced expression of HOPX enhanced cellular senescence via activation of oncogenic Ras and the downstream MAPK pathway, which in turn led to decreased MDM2 and increased p21.
|
25345926 |
2015 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
PC tissues had HOPX gene hypermethylation as compared to the corresponding normal pancreas tissues, and its uniqueness was robust to discriminate tumor from normal tissues (AUC = 0.85, P < 0.0001).
|
22958219 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Decreased expression of CHIP in proliferating cancer cells is in keeping with its proposed tumor suppressor properties, while over-expression of HOP in proliferating cells may contribute to excessive Hsp90 activity and stabilization of client proteins in tumors.
|
22669480 |
2012 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer.
|
20228841 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HOPX (homeodomain only protein X) is a newly identified homeobox gene whose loss of expression has been reported for several types of neoplasm.
|
19173292 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In conclusion, HOP is a putative TSG that harbors tumor inhibitory activity, and we for the first time showed that the final shutdown process of HOP expression is linked to promoter DNA hypermethylation under the double control of the discrete promoter regions in cancer.
|
18234960 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, HOP may work as a tumor suppressor in a subset of glioblastomas.
|
18507846 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HOP positive transfectants remarkably reduced the growth rate and the ability of anchorage-independent growth in soft agar, and moreover suppressed the tumor formation in nude mice compared to controls.
|
17417779 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).
|
15213722 |
2004 |