DGAT2, diacylglycerol O-acyltransferase 2, 84649

N. diseases: 41; N. variants: 4
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.040 Biomarker disease BEFREE Consistent with prior reports, chronic inhibition of DGAT2 in a murine model of obesity led to correction of multiple lipid parameters. 29706567 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.040 GeneticVariation disease BEFREE We detected two rare variants in DGAT2 with no significant difference between obese and lean individuals. 28243972 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.040 AlteredExpression disease BEFREE Only subcutaneous expression of these genes tracked with obesity levels as reflected by significant positive associations between subcutaneous fat CEBPalpha, SREBP1c and DGAT2 expression and total body fat mass (r=0.37, r=0.41, r=0.57, respectively, P< or =0,05), fat percentage (r=0.40, r=0.39, r=058, respectively, P< or =0,05) and subcutaneous adipose tissue area (r=0.36, r=0.38, r=0.58, respectively, P< or =0,05). 17726433 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.040 GeneticVariation disease BEFREE In conclusion, our results do not support the hypothesis of an important role of common genetic variation in DGAT2 for the development of obesity in our sample. 17477860 2007