DisGeNET - a database of gene-disease associations

TRIM63, tripartite motif containing 63, 84676

N. diseases: 73; N. variants: 4

Disease: Chronic Kidney Diseases ×

Source: ALL

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Disease

Score _gda

Association Type

Type

Original DB

Sentence supporting the association

PMID

PMID Year

CUI:	C1561643
Disease:	Chronic Kidney Diseases

Chronic Kidney Diseases

0.030

AlteredExpression

group

BEFREE

In contrast, Atrolnc-1 knockdown attenuates muscle wasting by 42% in mice with CKD via suppression of NF-κB activity and MuRF-1 expression.

30043444

2018

CUI:	C1561643
Disease:	Chronic Kidney Diseases

Chronic Kidney Diseases

0.030

AlteredExpression

group

BEFREE

Knockdown of SCP4 significantly suppressed FoxO1/3a-mediated expression of Atrogin-1 and MuRF-1 and prevented muscle wasting in mice with CKD.

28506762

2017

CUI:	C1561643
Disease:	Chronic Kidney Diseases

Chronic Kidney Diseases

0.030

AlteredExpression

group

BEFREE

Here, we showed that resveratrol prevented an increase in MuRF1 expression and attenuated muscle atrophy in vivo model of CKD.

28392400

2017