IRS4, insulin receptor substrate 4, 8471

N. diseases: 35; N. variants: 0
Disease: Subungual exostoses ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038604
Disease: Subungual exostoses
Subungual exostoses 		0.020 AlteredExpression disease BEFREE IRS4 overexpression has been associated with acute lymphoblastic leukaemia and subungual exostosis, while point mutations of IRS4 have been found in melanomas. 24039912 2013
CUI: C0038604
Disease: Subungual exostoses
Subungual exostoses 		0.020 AlteredExpression disease BEFREE As the t(X;6) usually is the sole cytogenetic aberration in subungual exostosis, the deregulated expression of IRS4 is likely to be pathogenetically essential. 20340132 2011