RSPO3, R-spondin 3, 84870

N. diseases: 64; N. variants: 22
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE Thus, we identified RSPO3 as a novel key modulator of breast cancer development and a potential target for treatment of basal-like breast cancers.<b>Significance:</b> These findings identify RSPO3 as a potential therapetuic target in basal-like breast cancers.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/16/4497/F1.large.jpg <i>Cancer Res; 78(16); 4497-511.©2018 AACR</i>. 29748375 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 GeneticVariation group BEFREE Consistent with a central role of Wnt signaling in regulation of gene expression, inhibition of PORCN in RSPO3-translocated cancers causes a marked remodeling of the transcriptome, with loss of cell cycle, stem cell and proliferation genes, and an increase in differentiation markers. 26257057 2016