SPPL2A, signal peptide peptidase like 2A, 84888

N. diseases: 22; N. variants: 10
Disease: Mycobacterium Infections ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026918
Disease: Mycobacterium Infections
Mycobacterium Infections 		0.010 Biomarker group BEFREE These findings suggest that inherited SPPL2a deficiency in humans underlies mycobacterial disease by decreasing the numbers of cDC2s and impairing IFN-γ production by mycobacterium-specific memory T<sub>H</sub>1* cells. 30127434 2018