|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined cord blood T and B cell immunity to P. falciparum merozoite surface protein-1 (MSP-1) in infants born in an area of stable malaria transmission in Kenya.
|
11751981 |
2002 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blood samples were collected from 142 patients with symptomatic malaria and typed using a polymerase chain reaction-based strategy for merozoite surface protein-(MSP-1) block 2, the MSP-2 central domain, and glutamate-rich protein (GLURP) repeat domain polymorphism.
|
10674682 |
1999 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite the extensive polymorphism at the merozoite surface protein-1 (MSP-1) locus of Plasmodium falciparum, that encodes a major repetitive malaria vaccine candidate antigen, identical and nearly identical alleles frequently occur in sympatric parasites.
|
12941155 |
2003 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inclusion of multiple Ag variants in subunit vaccine candidates is one strategy that has aimed to overcome this problem for the leading blood-stage malaria vaccine targets, that is, merozoite surface protein 1 (MSP1) and apical membrane Ag 1 (AMA1).
|
23293353 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The merozoite surface protein-1 (MSP-1) gene encodes for a leading malaria vaccine candidate antigen.
|
30518419 |
2018 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The type of msp-1 allele detected was significantly associated with the clinical category of malaria.
|
16023985 |
2005 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to determine the genetic diversity of Plasmodium falciparum by analyzing the polymorphism of the msp-1 and msp-2 genes and the multiplicity of infection in children with uncomplicated malaria in southern Benin.
|
24135216 |
2013 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study examined the extension and immunological relevance of the allelic polymorphism of the MSP1(19) from Plasmodium vivax, a major human malaria parasite.
|
10449807 |
1999 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we assess serum antibody responses against both the MSP1 and AMA1 antigens following i) ChAd63-MVA immunization, ii) immunization and CHMI, and iii) primary malaria exposure in the context of CHMI in unimmunized control volunteers.
|
25254500 |
2014 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, this study supports the use of msp1, msp2 and glurp in malaria clinical trials in sub-Saharan Africa to discriminate new from recrudescent infections.
|
21470428 |
2011 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Allelic dimorphism is a characteristic feature of the Plasmodium falciparum msp1 gene encoding the merozoite surface protein 1, a strong malaria vaccine candidate.
|
17574779 |
2007 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-terminal of MSP-1 gene were amplified from 126 clinical samples collected from imported cases of malaria in migrant workers returning to Jiangsu Province from Africa using a conventional polymerase chain reaction (PCR) assay.
|
30446012 |
2018 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Allelic recombination and linkage disequilibrium within Msp-1 of Plasmodium falciparum, the malignant human malaria parasite.
|
10196473 |
1999 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied MSP1 and MSP2 diversity in parasites collected from subjects with both symptomatic (n = 86) and asymptomatic (34) malaria living on the island of Santo, Vanuatu, an area of stable malaria transmission.
|
10811274 |
2000 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extensive polymorphism in msp-1 gene has been reported in P. vivax isolates from different geographical regions which is necessary before a field trial of any malaria vaccine based on msp-1 is undertaken.
|
20090136 |
2009 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that fetal sensitization or tolerance to MSP-1, associated with maternal malaria infection during pregnancy, affects the development of functional Ab responses to MSP-1 during infancy.
|
17082631 |
2006 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The finding that antibodies to a small region of a single protein play a major role in this process has important implications for malaria immunity and is strongly supportive of further understanding and development of MSP-1(19)-based vaccines.
|
11413195 |
2001 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conducted a genome-wide association study (GWAS) of antibody responses directed to three Plasmodium falciparum vaccine candidate antigens (MSP1, MSP2 and GLURP) previously associated with different patterns of protection against malaria infection in Senegalese children.
|
26741287 |
2016 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasmodium falciparum merozoite surface protein-1(19) (MSP-1(19)) is a prime candidate for a blood-stage malaria vaccine.
|
16055071 |
2005 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Merozoite surface protein1 (MSP1) is a leading blood-stage malaria vaccine candidate, and anti-MSP1 antibodies from individuals that are clinically immune to malaria inhibit the invasion of Plasmodium merozoites into erythrocytes in vitro.
|
16861644 |
2006 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In an epidemiological study in an area holoendemic for malaria in Ghana, the prevalence and multiplicity of P. falciparum infections (MOI) were assessed in 1069 three month-old infants by typing of the genes encoding the merozoite surface proteins 1 and 2 (msp-1, msp-2) over a recruitment period of one year.
|
16640613 |
2006 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have examined here the allelic diversity of P. falciparum and attempted to understand the polymorphism and distribution of alleles of MSP1 with transition in transmission season and with differences in malaria epidemiology between sites.
|
19454325 |
2009 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
A molecular study using the merozoite surface protein 1 (msp-1) gene as a marker was performed on 24 P. vivax genomic isolates from 12 indigenous and 10 imported malaria cases that occurred in the Surkhandarya region during the summer of 2002.
|
15289095 |
2004 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, a major concern in the development of MSP-1 based malaria vaccine is the polymorphism observed in different geographical Plasmodium falciparum isolates.
|
17659072 |
2007 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The predominant MSP1 allelic families were MAD20 for uncomplicated malaria and RO33 for severe malaria.
|
27350250 |
2016 |